Taylor D W, Siddiqui W A
J Parasitol. 1979 Apr;65(2):267-71.
The relationship among geographic origin, phenotype, karyotype, and susceptibility of owl monkeys to 2 strains of Plasmodium falciparum was investigated. Owl monkeys from Columbia and Panama were both susceptible to fatal infections with the Asian FVO (Vietnam-Oak Knoll) strain of P. falciparum. However, when inoculated with the African FUP (Uganda-Palo Alto) strain, most Colombian owl monkeys developed fatal or potentially fatal (bled out with parasitemias of over 25%) infections, but Panamanian monkeys generally survived. Colombian and Panamanian monkeys that spontaneously recovered from malaria infection were phenotypically indistinguishable from those which died. Karyotype analysis revealed that animals considered in this study were either Karyotype II (54 chromosomes) or II (53 chromosomes). Karyotype differences between individual monkeys did not correlate with increased susceptibility or resistance to malaria. Thus, the country of origin of owl monkeys appears to play a more important role in host susceptibility to malaria infection than karyotype.
研究了夜猴的地理起源、表型、核型与对2种恶性疟原虫菌株易感性之间的关系。来自哥伦比亚和巴拿马的夜猴均易死于亚洲FVO（越南-橡树山）株恶性疟原虫感染。然而，当接种非洲FUP（乌干达-帕洛阿尔托）株时，大多数哥伦比亚夜猴发生了致命或潜在致命（寄生虫血症超过25%时失血过多）的感染，但巴拿马夜猴通常存活下来。从疟疾感染中自发恢复的哥伦比亚和巴拿马夜猴在表型上与死亡的夜猴没有区别。核型分析表明，本研究中的动物要么是核型II（54条染色体），要么是II（53条染色体）。个体夜猴之间的核型差异与疟疾易感性或抗性增加无关。因此，夜猴的原产国在宿主对疟疾感染的易感性方面似乎比核型发挥更重要的作用。
