Chey J, Kim J W, Cho H Y
Department of Psychology, Psychological Health Institute, Sungshin Women's University, Seoul, South Korea.
Neurosci Lett. 2000 Aug 11;289(3):230-4. doi: 10.1016/s0304-3940(00)01288-x.
Studies have demonstrated that different apolipoprotein E (APOE) phenotypes appear to modulate the effects of cognitive aging in Caucasian elderly populations. Few studies have investigated the effects of the common APOE alleles on the neuropsychological functioning in other ethnic elderly populations. We examined the different effects of APOE polymorphism on the neuropsychological functions of 213 community-dwelling Korean elderly individuals without dementia. Individuals with APOE epsilon4 allele performed poorly on memory measures, Recency of the Elderly Verbal Learning Test, Immediate and Delayed Reproductions of the Simplified Rey Figure Test (SRFT), the Primary Memory Index, and the Secondary Memory Index. They also performed worse on the sub-scale assessing executive function on the Korean-Dementia Rating Scale (K-DRS). Subjects with APOE epsilon2 allele performed better on visuo-spatial measures, the Construction sub-scale of the K-DRS, and the Copy and Immediate Reproductions of the SRFT.
研究表明，不同的载脂蛋白E（APOE）表型似乎可调节高加索老年人群认知衰老的影响。很少有研究调查常见APOE等位基因对其他种族老年人群神经心理功能的影响。我们研究了APOE基因多态性对213名无痴呆症的社区居住韩国老年人神经心理功能的不同影响。携带APOEε4等位基因的个体在记忆测试、老年言语学习测试的新近记忆、简化雷氏图形测试（SRFT）的即时和延迟复制、初级记忆指数和次级记忆指数上表现较差。他们在韩国痴呆评定量表（K-DRS）中评估执行功能的子量表上也表现更差。携带APOEε2等位基因的受试者在视觉空间测试、K-DRS的构建子量表以及SRFT的复制和即时复制方面表现更好。
