Piskunowicz Małgorzata T, Linkowska Katarzyna, Gołota Szymon, Grzybowski Tomasz, Kędziora-Kornatowska Kornelia, Borkowska Alina
1 Collegium Medicum, 49604 Uniwersytet Mikolaja Kopernika , Bydgoszcz, Poland.
Int J Aging Hum Dev. 2018 Sep;87(2):124-140. doi: 10.1177/0091415017724548. Epub 2017 Aug 28.
The ε4 allele of the apolipoprotein E (APOE) gene is known as a risk factor for dementia. How APOE ε polymorphism affects cognitive performance in nondemented aging subjects remains less clear. In this study, the relationship between APOE status and cognitive performance across various cognitive domains in adults aged 55 to 75 years ( n = 74) without dementia was investigated. E4 carriers ( n = 11) performed worse versus noncarriers on forward Digit Span and delayed recall of the Rey-Osterrieth complex figure. General linear model analysis revealed a small but significant main effect of ε4 on Rey-Osterrieth complex figure delayed recall. Comparing ε2 carriers, ε3 homozygotes, and ε4 carriers, ε3/ε3 performed significantly better on Trail Making Test part B and derived score Trail Making Test B-A. The findings support the relation between the APOE ε polymorphism and visual memory, short-term auditory memory, visuospatial attention, and executive functions in an aging sample without dementia.
载脂蛋白E（APOE）基因的ε4等位基因是已知的痴呆风险因素。APOEε多态性如何影响未患痴呆的老年受试者的认知表现仍不太清楚。在本研究中，调查了55至75岁（n = 74）无痴呆的成年人中APOE状态与各认知领域认知表现之间的关系。E4携带者（n = 11）在顺背数字广度和雷-奥斯特里思复杂图形延迟回忆方面的表现比非携带者差。一般线性模型分析显示，ε4对雷-奥斯特里思复杂图形延迟回忆有微小但显著的主效应。比较ε2携带者、ε3纯合子和ε4携带者，ε3/ε3在连线测验B部分和衍生分数连线测验B-A上的表现明显更好。这些发现支持了在无痴呆的老年样本中，APOEε多态性与视觉记忆、短期听觉记忆、视觉空间注意力和执行功能之间的关系。
