聚果榕叶提取物的抗炎评估

Anti-inflammatory evaluation of Ficus racemosa Linn. leaf extract.

作者信息

Mandal S C, Maity T K, Das J, Saba B P, Pal M

机构信息

Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University, Calcutta 700 032, India.

出版信息

J Ethnopharmacol. 2000 Sep;72(1-2):87-92. doi: 10.1016/s0378-8741(00)00210-5.

DOI:10.1016/s0378-8741(00)00210-5

PMID:10967458

Abstract

The anti-inflammatory activity of Ficus racemosa extract was evaluated on carrageenin, serotonin, histamine and dextran-induced rat hind paw oedema models. The extract at doses of 200 and 400 mg/kg has been found to possess significant anti-inflammatory activity on the tested experimental models. The extract (400 mg/kg) exhibited maximum anti-inflammatory effect, that is 30.4, 32.2, 33.9 and 32.0% at the end of 3 h with carrageenin, serotonin, histamine, dextran-induced rat paw oedema, respectively. In a chronic test the extract (400 mg/kg) showed 41.5% reduction in granuloma weight. The effect produced by the extract was comparable to that of phenylbutazone, a prototype of a non-steroidal anti-inflammatory agent.

摘要

对无花果提取物的抗炎活性在角叉菜胶、血清素、组胺和右旋糖酐诱导的大鼠后爪水肿模型上进行了评估。已发现剂量为200和400mg/kg的提取物在测试的实验模型上具有显著的抗炎活性。提取物（400mg/kg）表现出最大的抗炎作用，在角叉菜胶、血清素、组胺、右旋糖酐诱导的大鼠爪水肿模型中，在3小时结束时分别为30.4%、32.2%、33.9%和32.0%。在慢性试验中，提取物（400mg/kg）使肉芽肿重量减轻了41.5%。提取物产生的效果与非甾体抗炎药原型苯基丁氮酮相当。