Barry M, Feely J
Department of Pharmacology and Therapeutics, Trinity College Medical School, St James's Hospital, Dublin, Ireland.
Clin Pharmacokinet. 1990 Aug;19(2):167-9. doi: 10.2165/00003088-199019020-00006.
The authors observed an interaction between allopurinol and both theophylline and warfarin in 2 patients. To determine the possible effect of allopurinol on hepatic oxidative metabolism a [14C]-aminophenazone (aminopyrine) breath test was performed before and during treatment with allopurinol 100mg daily in 5 patients with hyperuricaemia. Allopurinol prolonged the [14CO2]-aminophenazone half-life from 72 +/- 13 to 104 +/- 16 minutes (mean +/- SEM, p less than 0.05). It is possible that allopurinol may produce clinically significant drug interactions through an inhibitory effect not only on xanthine oxidase metabolism but also on oxidative metabolism.
作者在2例患者中观察到别嘌醇与茶碱和华法林之间存在相互作用。为确定别嘌醇对肝脏氧化代谢的可能影响，对5例高尿酸血症患者在每日服用100mg别嘌醇治疗前及治疗期间进行了[14C] -氨基比林（氨基苯磺隆）呼气试验。别嘌醇使[14CO2] -氨基比林半衰期从72±13分钟延长至104±16分钟（平均值±标准误，p<0.05）。别嘌醇不仅可能通过对黄嘌呤氧化酶代谢的抑制作用，还可能通过对氧化代谢的抑制作用产生具有临床意义的药物相互作用。
