Peter E
Arzneimittelforschung. 1975 Feb;25(2A):324-5.
27 patients with ascertained ankylosing spondylitis experiencing constant after-midnight-pain received, following three medication-free days, in a double blind, randomized, cross-over fashion indometacin (100 g/day) and d-2-(6'-methoxy-2'-naphthyl)-propionic acid (naproxen) (500 mg/day), as suppositories, for a period of six days each. The intensity of the night-pain was recorded daily. Naproxen was shown to be equally effective as indometacin in alleviating the after-midnight backache of ankylosing spondylitis. Side effects occurred under indometacin in 5 cases, under naproxen in 3 cases.
27例确诊为强直性脊柱炎且午夜后持续疼痛的患者，在三个无用药日之后，以双盲、随机、交叉方式，分别接受吲哚美辛（100毫克/天）和d-2-（6'-甲氧基-2'-萘基）-丙酸（萘普生）（500毫克/天）的栓剂治疗，各为期6天。每天记录夜间疼痛强度。结果显示，萘普生在缓解强直性脊柱炎午夜后背痛方面与吲哚美辛同样有效。使用吲哚美辛时有5例出现副作用，使用萘普生时有3例出现副作用。
