Murakami Y, Nagae S, Matsuishi E, Irie K, Furue M
Department of Dermatology, Faculty of Medicine, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan.
Br J Dermatol. 2000 Sep;143(3):587-90. doi: 10.1111/j.1365-2133.2000.03714.x.
We describe a 70-year-old man with cutaneous granulocytic sarcoma who presented with numerous cutaneous nodules but without any leukaemic involvement of the peripheral blood. The tumour cells were positive for lysozyme, peroxidase, CD11a, CD11c, CD33 and HLA-DR, and weakly positive for CD4 and CD14, suggesting granulocytic differentiation. The bone marrow at admission showed dysplasia of the erythrocytic and granulocytic lineage and complex chromosomal abnormalities in association with an increase in monocytes. The patient was diagnosed as having granulocytic sarcoma of monocytic lineage with concomitant myelodysplastic syndrome. In this case, tumour cells also expressed the neural cell adhesion molecule (CD56), which has been suggested as a possible risk factor for developing granulocytic sarcoma in acute myelogenous leukaemia.
我们描述了一名70岁患有皮肤粒细胞肉瘤的男性，其表现为大量皮肤结节，但外周血无任何白血病累及。肿瘤细胞溶菌酶、过氧化物酶、CD11a、CD11c、CD33和HLA-DR呈阳性，CD4和CD14呈弱阳性，提示粒细胞分化。入院时骨髓显示红细胞系和粒细胞系发育异常以及伴有单核细胞增多的复杂染色体异常。该患者被诊断为单核细胞系粒细胞肉瘤伴发骨髓增生异常综合征。在这种情况下，肿瘤细胞还表达神经细胞黏附分子（CD56），这被认为是急性髓性白血病发生粒细胞肉瘤的一个可能危险因素。
