Hollister L E, Gillespie H
Clin Pharmacol Ther. 1975 Jul;18(1):80-3. doi: 10.1002/cpt197518180.
Oral doses of delta-9-tetrahydrocannabinol (THC) 20 mg, combined with placebo or with 40 mg dses of cannabinol (CBN) and cannabidiol (CBD), were given to volunteers. The combination of THC with CBN produced no detectable changes in the quality, intensity, or duration of the effects of THC alone. The THC-CBD combination tended to delay onset and prolong effects of THC, while making them somewhat more intense. Even this interactive effect was slight, providing no reason to abandon the current practice of basing doses of marihuana for clinical studies solely on THC content.
给志愿者口服20毫克的δ-9-四氢大麻酚（THC），并搭配安慰剂，或40毫克的大麻酚（CBN）和大麻二酚（CBD）。THC与CBN的组合未使单独使用THC时的效果在质量、强度或持续时间上产生可检测到的变化。THC与CBD的组合往往会延迟THC的起效时间并延长其效果，同时使其效果略有增强。即便这种相互作用效应很轻微，但这也没有理由摒弃目前在临床研究中仅根据THC含量来确定大麻剂量的做法。
