Diebold J, Molina T, Camilleri-Broët S, Le Tourneau A, Audouin J
Service Central 'Jacques-Delarue' d'Anatomie et de Cytologie Pathologiques, Hôtel-Dieu, Paris, France.
Histopathology. 2000 Sep;37(3):199-211. doi: 10.1046/j.1365-2559.2000.00965.x.
Bone marrow modifications resulting from infections and systemic diseases can be studied by analysis of morphology and aetiology. Two types of lesions or modifications can be observed, those occurring in the connective tissue comprising inflammatory processes, acute and chronic, as well as immune reactions, and those involving the normal haematopoietic cell lines, with possible hyperplastic or aplastic changes in one or more cell lines. The main lesions are described (oedema, haemorrhage, necrosis, suppuration, granulomas, lymphoid nodules and hyperplasia, immunoblastic or plasmacytic hyperplasia), as well as the main aetiologies. In association, the three main haematopoietic cell lines show hyperplasia, hypoplasia, aplasia of one or all of the cell lines, sometimes with dysmyelopoiesis. The stroma and vessel reactions comprise myelofibrosis, gelatinous transformation or amyloid deposits. The methods for identifying aetiological agents are emphasized. It should also be stressed that malignant neoplasias of different types involving the bone marrow can be responsible for such inflammatory or immune reactions.
通过对形态学和病因学的分析，可以研究由感染和全身性疾病引起的骨髓改变。可以观察到两种类型的病变或改变，一种发生在结缔组织中，包括急性和慢性炎症过程以及免疫反应，另一种涉及正常造血细胞系，一个或多个细胞系可能出现增生或发育不全的变化。描述了主要病变（水肿、出血、坏死、化脓、肉芽肿、淋巴小结和增生、免疫母细胞或浆细胞增生）以及主要病因。此外，三种主要造血细胞系可出现一个或所有细胞系的增生、发育不全、再生障碍，有时伴有骨髓生成异常。基质和血管反应包括骨髓纤维化、胶样变性或淀粉样沉积。文中强调了识别病原体的方法。还应强调的是，涉及骨髓的不同类型恶性肿瘤可导致此类炎症或免疫反应。
