Seiter S, Ugurel S, Tilgen W, Reinhold U
Department of Dermatology, The Saarland University Hospital, Homburg/Saar, Germany.
Int J Dermatol. 2000 Aug;39(8):624-7. doi: 10.1046/j.1365-4362.2000.00006.x.
Although there are several treatment options available for patients with generalized vitiligo, their efficacy is still a matter of debate. Although shown to be effective, corticosteroids applied either systemically or topically carry the risk of significant side-effects in long-term therapy. We evaluated the effectiveness of intravenous methylprednisolone (8 mg/kg body weight) administered on three consecutive days in patients with generalized vitiligo.
A total of 14 patients with progressive or static vitiligo were included in a prospective, open, clinical study.
Eighty-five per cent of the patients presenting with progressive disease showed cessation of disease progression after the infusion therapy. Repigmentation was observed in 71% of patients with progressive vitiligo. None of the six patients presenting with static disease showed any repigmentation in response to this form of treatment. The therapy was well tolerated in all but one patient who developed intermittent arterial hypertension during therapy.
High-dose glucocorticoid pulse therapy may represent a therapeutic option in patients with generalized progressive vitiligo, and should be further evaluated in a prospective, randomized, clinical trial.
尽管对于泛发性白癜风患者有多种治疗选择，但其疗效仍存在争议。虽然全身或局部应用皮质类固醇已显示有效，但长期治疗存在显著副作用风险。我们评估了连续三天静脉注射甲泼尼龙（8毫克/千克体重）对泛发性白癜风患者的有效性。
一项前瞻性、开放性临床研究纳入了总共14例进展期或静止期白癜风患者。
85%的进展期疾病患者在输注治疗后疾病进展停止。71%的进展期白癜风患者出现色素再生。6例静止期疾病患者中无一例对这种治疗形式有任何色素再生反应。除1例患者在治疗期间出现间歇性动脉高血压外，所有患者对该治疗耐受性良好。
大剂量糖皮质激素脉冲疗法可能是泛发性进展期白癜风患者的一种治疗选择，应在前瞻性、随机临床试验中进一步评估。
