Zeisler S K, Becker D W, Pavan R A, Moschel R, Rühle H
German Cancer Research Center (DKFZ), Department of Radiochemistry, Heidelberg.
Appl Radiat Isot. 2000 Sep;53(3):449-53. doi: 10.1016/s0969-8043(99)00254-7.
A new automated target system for the routine production of [18F]fluoride from (18)O-enriched water has been constructed. It consists of a small spherical niobium target chamber mounted into a special holder, which provides rapid cooling by water flow around the sphere. The target is irradiated with 21 MeV protons; the incident energy in the target chamber is 13 MeV. The system is operated without external over-pressure and has been tested for beam currents up to 50 microA. 95% of the theoretical yield of [18F]fluoride has been extracted and used for the synthesis of [18F]2-fluoro-2-deoxy-D-glucose.
