抑制后脱氧核糖核酸合成的速率刺激
Rate stimulation of deoxyribonucleic acid synthesis after inhibition.
作者信息
Zaritsky A
出版信息
J Bacteriol. 1975 Jun;122(3):841-6. doi: 10.1128/jb.122.3.841-846.1975.
Abstract
The degree to which the rate of deoxyribonucleic acid synthesis in thy- cultures of Escherichia coli is stimulated after a period of thymine starvation is shown to be a function of the concentration of thymine present as well as of the culture doubling time. Inhibition of deoxyribonucleic acid synthesis by nalidixic acid yields comparable results. Periods of thymine starvation exceeding one doubling time appear to cause an irreversible inactivation of a fraction of the replication forks in the culture.
摘要
结果表明，在一段时间的胸腺嘧啶饥饿后，大肠杆菌培养物中脱氧核糖核酸合成速率的受刺激程度是胸腺嘧啶当前浓度以及培养物倍增时间的函数。萘啶酸对脱氧核糖核酸合成的抑制产生了类似的结果。超过一个倍增时间的胸腺嘧啶饥饿期似乎会导致培养物中一部分复制叉发生不可逆的失活。
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