Laboratory of Microbiology Signals and Microenvironment, Theoretical Biology Unit, University of Rouen, Mont Saint Aignan France.
Front Microbiol. 2015 Apr 16;6:322. doi: 10.3389/fmicb.2015.00322. eCollection 2015.
The problem of not only how but also why cells divide can be tackled using recent ideas. One idea from the origins of life - Life as independent of its constituents - is that a living entity like a cell is a particular pattern of connectivity between its constituents. This means that if the growing cell were just to get bigger the average connectivity between its constituents per unit mass - its cellular connectivity - would decrease and the cell would lose its identity. The solution is division which restores connectivity. The corollary is that the cell senses decreasing cellular connectivity and uses this information to trigger division. A second idea from phenotypic diversity - Life on the Scales of Equilibria - is that a bacterium must find strategies that allow it to both survive and grow. This means that it has learnt to reconcile the opposing constraints that these strategies impose. The solution is that the cell cycle generates daughter cells with different phenotypes based on sufficiently complex equilibrium (E) and non-equilibrium (NE) cellular compounds and structures appropriate for survival and growth, respectively, alias 'hyperstructures.' The corollary is that the cell senses both the quantity of E material and the intensity of use of NE material and then uses this information to trigger the cell cycle. A third idea from artificial intelligence - Competitive Coherence - is that a cell selects the active subset of elements that actively determine its phenotype from a much larger set of available elements. This means that the selection of an active subset of a specific size and composition must be done so as to generate both a coherent cell state, in which the cell's contents work together harmoniously, and a coherent sequence of cell states, each coherent with respect to itself and to an unpredictable environment. The solution is the use of a range of mechanisms ranging from hyperstructure dynamics to the cell cycle itself.
细胞不仅如何分裂,而且为何分裂的问题可以用最近的观点来解决。生命起源的一个观点——生命独立于其组成部分——是指像细胞这样的生物体是其组成部分之间特定的连接模式。这意味着,如果生长中的细胞只是变大,那么其组成部分之间每单位质量的平均连接性——细胞连接性——就会降低,细胞就会失去其特性。解决办法是分裂,它可以恢复连接性。其推论是细胞感知到细胞连接性下降,并利用这一信息来触发分裂。表型多样性的另一个观点——平衡尺度上的生命——是指细菌必须找到既能生存又能生长的策略。这意味着它已经学会了调和这些策略所施加的相反的约束。解决方案是细胞周期根据足够复杂的平衡(E)和非平衡(NE)细胞化合物和结构产生具有不同表型的子细胞,分别适合生存和生长,别名“超结构”。其推论是细胞感知 E 物质的数量和 NE 物质的使用强度,然后利用这一信息来触发细胞周期。人工智能的另一个观点——竞争一致性——是指细胞从更大的可用元素集合中选择积极决定其表型的元素的活跃子集。这意味着必须选择特定大小和组成的活跃子集,以产生既具有一致细胞状态的,其中细胞的内容和谐地协同工作,又具有一致的细胞状态序列,每个状态都与自身以及不可预测的环境保持一致。解决方案是使用一系列机制,从超结构动力学到细胞周期本身。