Bjordal K, de Graeff A, Fayers P M, Hammerlid E, van Pottelsberghe C, Curran D, Ahlner-Elmqvist M, Maher E J, Meyza J W, Brédart A, Söderholm A L, Arraras J J, Feine J S, Abendstein H, Morton R P, Pignon T, Huguenin P, Bottomly A, Kaasa S
The Department of Radiotherapy and Oncology, The Norwegian Radium Hospital, Montebello, N-0310, Oslo, Norway.
Eur J Cancer. 2000 Sep;36(14):1796-807. doi: 10.1016/s0959-8049(00)00186-6.
This study tests the reliability and validity of the European Organization for Research and Treatment of Cancer (EORTC) head and neck cancer module (QLQ-H&N35) and version 3.0 of the EORTC Core Questionnaire (QLQ-C30) in 622 head and neck cancer patients from 12 countries. The patients completed the QLQ-C30, the QLQ-H&N35 and a debriefing questionnaire before antineoplastic treatment or at a follow-up. 232 patients receiving treatment completed a second questionnaire after treatment. Compliance was high and the questionnaire was well accepted by the patients. Multitrait scaling analysis confirmed the proposed scale structure of the QLQ-H&N35. The QLQ-H&N35 was responsive to differences between disease status, site and patients with different Karnofsky performance status, and to changes over time. The new physical functioning scale (with a four-point response format) of version 3.0 of the QLQ-C30 was shown to be more reliable than previous versions. Thus, the QLQ-H&N35, in conjunction with the QLQ-C30, appears to be reliable, valid and applicable to broad multicultural samples of head and neck cancer patients.
本研究对欧洲癌症研究与治疗组织（EORTC）头颈部癌模块（QLQ-H&N35）以及EORTC核心问卷3.0版（QLQ-C30）在来自12个国家的622名头颈部癌患者中的信度和效度进行了测试。患者在接受抗肿瘤治疗前或随访时完成了QLQ-C30、QLQ-H&N35及一份情况汇报问卷。232名接受治疗的患者在治疗后完成了第二份问卷。依从性很高，问卷也很受患者欢迎。多特质量表分析证实了QLQ-H&N35所提议的量表结构。QLQ-H&N35对疾病状态、部位以及不同卡诺夫斯基表现状态的患者之间的差异，以及随时间的变化有反应。QLQ-C30 3.0版新的身体功能量表（采用四点反应格式）比之前版本更可靠。因此，QLQ-H&N35与QLQ-C30结合使用时，似乎对头颈部癌患者的广泛多元文化样本具有可靠性、有效性和适用性。
