Fontaine P
Clinique Marc Linquette, CHRU de Lille.
Diabetes Metab. 2000 Jun;26 Suppl 2:16-9.
Postprandial blood glucose peaks are essential to consider in the high-risk situation featured by pregnancy in diabetic women, through several aspects. First, from a diagnostic point of view, post-stimulative situation offers the optimal sensitivity and specificity for a proper gestational diabetes screening. Next, when considering foetomaternal complications, third term postprandial hyperglycemia is highly predictive of child birth weight. Last, regarding metabolic monitoring, taking postprandial blood glucose into account leads to increasing insulin dosage, improving final term HbA1c and, finally, a lower average birth weight. However, it is mandatory for a proper management to avoid borderline glycemia, as blood glucose peaks are useful for fetal growth.
对于糖尿病女性妊娠这种高危情况,餐后血糖峰值需要从多个方面加以考虑。首先,从诊断角度来看,刺激后状态为进行恰当的妊娠期糖尿病筛查提供了最佳的敏感性和特异性。其次,在考虑母婴并发症时,孕晚期餐后高血糖对胎儿出生体重具有高度预测性。最后,在代谢监测方面,将餐后血糖纳入考量会导致胰岛素剂量增加,改善孕晚期糖化血红蛋白水平,最终降低平均出生体重。然而,为了进行恰当的管理,避免血糖处于临界值至关重要,因为血糖峰值对胎儿生长有益。