Chalmers M J, Gaskell S J
Michael Barber Centre for Mass Spectrometry, Department of Chemistry, UMIST, Manchester, UK.
Curr Opin Biotechnol. 2000 Aug;11(4):384-90. doi: 10.1016/s0958-1669(00)00114-2.
The most demanding problems in proteomics continue to challenge modern mass spectrometry. Recent developments in instrument design have led to lower limits of detection, while new ion activation techniques and improved understanding of gas-phase ion chemistry have enhanced the capabilities of tandem mass spectrometry for peptide and protein structure elucidation. Future developments must address the., understanding of protein-protein interactions and the characterisation of the dynamic proteome.
