Nakamura H, Hashimoto T, Yagyuu H, Sudou A, Sarashina G, Hatao E, Tuchida F, Adachi H, Kishi K, Kashiwabara K, Matsuoka T
Fifth Department of Internal Medicine, Tokyo Medical College, Ibaraki, Japan.
Nihon Kokyuki Gakkai Zasshi. 2000 Jun;38(6):452-5.
Sarcoidosis is known to be a disease characterized by high familial aggregations. We reported on the genealogy of sarcoidosis in a man and his identical twin sons. The patient we encountered was a 49-year-old man admitted to our hospital because of abnormal chest X-ray findings observed during a medical checkup. Cervical and hilar lymph nodes were swollen on both sides, and lesions were observed in the right lung field. Biopsy specimens from cervical lymph nodes disclosed epithelioid cell granuloma without caseous necrosis. A diagnosis of sarcoidosis was made. The disease had also been diagnosed in the patient's identical twin sons 2 years earlier. They had been successfully treated and no recurrence has been observed. HLA typing disclosed that the father and his twin sons had identical A 33 (19), B 44 (12), DR 2, and DR 12 genes. This finding suggested that genetic factors are involved in the onset of this disease.
结节病是一种以高度家族聚集为特征的疾病。我们报告了一名男子及其同卵双胞胎儿子的结节病家族谱系。我们遇到的患者是一名49岁男性，因体检时胸部X线检查结果异常而入院。双侧颈部和肺门淋巴结肿大，右肺野可见病变。颈部淋巴结活检标本显示上皮样细胞肉芽肿，无干酪样坏死。诊断为结节病。该疾病在患者的同卵双胞胎儿子中两年前也被诊断出。他们已成功接受治疗，未观察到复发。HLA分型显示父亲及其双胞胎儿子具有相同的A 33(19)、B 44(12)、DR 2和DR 12基因。这一发现表明遗传因素与该疾病的发病有关。
