Nabeshima T
Department of Ophthalmology, Iwate Medical University School of Medicine, Morioka, Japan.
Nippon Ganka Gakkai Zasshi. 2000 Aug;104(8):547-54.
In order to use multifocal electroretinogram (m-ERG) for clinical assessment, we investigated the effects of aging on waves of the first and second order kernels of the m-ERG.
m-ERGs were recorded from 93 eyes (refractive error 0-(-)3.0 D) of 56 normal subjects (range 12-79, mean 44.2 +/- 20.7 years of age) using the Visual Evoked Response Imaging System (VERIS Science, version 3.0.1). We analyzed effects of aging on the response densities and the peak latencies of the first positive wave (P 1) of the first order kernel and the second and third positive waves (P 2 and P 3) of the second order kernel.
The response densities of the P 1 and P 2 waves significantly decreased, and the peak latencies of the P 1, P 2 and P 3 were significantly prolonged (p < 0.05) in the subjects above 50 years old.
The results suggested that the aging effect on the m-ERG should be considered when evaluating retinal function using m-ERGs in basic and clinical studies.
为了将多焦视网膜电图（m-ERG）用于临床评估，我们研究了年龄对m-ERG一阶和二阶核波的影响。
使用视觉诱发电位成像系统（VERIS Science，版本3.0.1），从56名正常受试者（年龄范围12 - 79岁，平均44.2±20.7岁）的93只眼（屈光不正0 - (-)3.0 D）记录m-ERG。我们分析了年龄对一阶核的第一个正波（P1）以及二阶核的第二个和第三个正波（P2和P3）的反应密度和峰值潜伏期的影响。
50岁以上受试者中，P1和P2波的反应密度显著降低，P1、P2和P3的峰值潜伏期显著延长（p < 0.05）。
结果表明，在基础和临床研究中使用m-ERG评估视网膜功能时，应考虑年龄对m-ERG的影响。
