Nabeshima Takashi, Tazawa Yutaka, Mita Mariko, Sano Marie
Department of Ophthalmology, Iwate Medical University School of Medicine, Morioka, Iwate, Japan.
Jpn J Ophthalmol. 2002 May-Jun;46(3):261-9. doi: 10.1016/s0021-5155(02)00475-6.
To determine the effects of aging on the first and second-order kernels of the multifocal electroretinogram (ERG).
Multifocal ERGs were recorded from 52 healthy subjects (52 eyes) (0 >or= refractive error >or= -3.0 diopter). The ages of the subjects ranged from 12-76 years with a mean (+/-SD) of 44.0 +/- 20.2 years. The Visual Evoked Response Imaging System was used. The effects of aging on the response densities and on the implicit times of the first positive wave (P1) of the first-order kernel, and of the second and third positive waves (P2 and P3) of the second-order kernel were analyzed for the different age groups.
The response densities of the first-order kernel P1 and second-order kernel P2 waves decreased significantly, and the implicit times of the second-order kernel P2, and P3 were significantly prolonged (P <.05) in subjects over 50 years of age.
The results suggest that the age of the subject should be considered when evaluating retinal function using multifocal ERGs in basic and clinical studies.
确定衰老对多焦视网膜电图（ERG）一阶和二阶核的影响。
对52名健康受试者（52只眼）（屈光不正范围为0≥屈光不正≥-3.0屈光度）记录多焦ERG。受试者年龄在12至76岁之间，平均（±标准差）为44.0±20.2岁。使用视觉诱发电位成像系统。分析不同年龄组中衰老对一阶核的第一个正波（P1）以及二阶核的第二个和第三个正波（P2和P3）的反应密度和隐含时间的影响。
50岁以上受试者中，一阶核P1波和二阶核P2波的反应密度显著降低，二阶核P2和P3的隐含时间显著延长（P<.05）。
结果表明，在基础和临床研究中使用多焦ERG评估视网膜功能时应考虑受试者的年龄。
