Cooper P J, Chico M E, Losonsky G, Sandoval C, Espinel I, Sridhara R, Aguilar M, Guevara A, Guderian R H, Levine M M, Griffin G E, Nutman T B
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
J Infect Dis. 2000 Oct;182(4):1199-206. doi: 10.1086/315837. Epub 2000 Sep 8.
Because concurrent infections with geohelminth parasites might impair the immune response to oral vaccines, we studied the vibriocidal antibody response to the oral cholera vaccine CVD 103-HgR in children infected with Ascaris lumbricoides and investigated the effect of albendazole pretreatment on the postvaccination response. Children with ascariasis were randomized to receive either 2 sequential doses of 400 mg of albendazole or placebo. After the second dose, CVD 103-HgR was given, and serum vibriocidal antibody levels were measured before and 10 days after vaccination. Postvaccination rates of seroconversion were greater in the treatment group that received albendazole (P=.06). Significantly greater rates of seroconversion and geometric mean titer were observed in the albendazole group in subjects with non-O ABO blood groups. A significant association was observed between vibriocidal seroconversion rates and treatment group, suggesting that A. lumbricoides infections impair the immune response to oral cholera vaccine, particularly in subjects of non-O blood groups.
由于土源性蠕虫寄生虫的并发感染可能会削弱对口服疫苗的免疫反应，我们研究了感染蛔虫的儿童对口服霍乱疫苗CVD 103-HgR的杀弧菌抗体反应，并调查了阿苯达唑预处理对疫苗接种后反应的影响。蛔虫病患儿被随机分为两组，分别接受连续2剂400mg阿苯达唑或安慰剂。在第二剂之后，给予CVD 103-HgR，并在接种疫苗前和接种后10天测量血清杀弧菌抗体水平。接受阿苯达唑治疗的组接种疫苗后的血清转化率更高（P = 0.06）。在非O型ABO血型的受试者中，阿苯达唑组的血清转化率和几何平均滴度显著更高。观察到杀弧菌血清转化率与治疗组之间存在显著关联，这表明蛔虫感染会削弱对口服霍乱疫苗的免疫反应，特别是在非O型血型的受试者中。
