Loewen N, Barry J C
Dept. II, Pathophysiology of Vision and Neuroophthalmology, Section for Ocular Motility Disorders, University Eye Hospital, Tübingen, Germany.
Strabismus. 2000 Jun;8(2):91-9.
Because of its advantages, topical cyclopentolate is often preferred over the gold standard, atropine. The purpose of this study was to obtain an overview over current cycloplegia protocols and to estimate the likelihood of severe complications due to the use of cycloplegics.
A questionnaire was sent to 107 German-speaking centers with a supposed high frequency of cycloplegias.
57 centers answered, whereby 1,112 cumulated years of experience with cycloplegia were available for analysis. The frequency of cycloplegias varied between 2 and 180/week/center, median 25/week/center. A cumulated total of 1.7 million cycloplegias was computed. The extrapolated average experience with cycloplegia was 49,000 cycloplegias/30 years. Complications which would warrant a medical follow-up of several hours (severe complications) or which led to a follow-up in a ward (very severe complications) were named 47 times and 2 times, respectively.
During 30 years of a cycloplegia career with an average of 34 cycloplegias/week, one may expect 2-10 severe or very severe complications. In current practice, the patient risk of severe complications is very small. Health care professionals and parents should be informed about the frequent occurrence of harmless side effects in order to achieve a good compliance with cycloplegia.
由于其优势，局部用环喷托酯通常比金标准药物阿托品更受青睐。本研究的目的是全面了解当前的睫状肌麻痹方案，并评估使用睫状肌麻痹剂导致严重并发症的可能性。
向107个德语地区、据推测睫状肌麻痹使用频率较高的中心发送了一份调查问卷。
57个中心回复，由此可分析出1112年的睫状肌麻痹累积经验。睫状肌麻痹的频率在每个中心每周2至180次之间，中位数为每周25次。计算得出睫状肌麻痹的累积总数为170万次。推算出的睫状肌麻痹平均经验为30年49000次。需要数小时医学随访（严重并发症）或导致在病房进行随访（非常严重并发症）的并发症分别被提及47次和2次。
在从事睫状肌麻痹工作的30年中，平均每周进行34次睫状肌麻痹，可能会出现2至10次严重或非常严重的并发症。在当前实践中，患者发生严重并发症的风险非常小。应告知医护人员和家长无害副作用频繁发生的情况，以便患者更好地配合进行睫状肌麻痹治疗。
