Pisegna J R
Division of Gastroenterology and Hepatology (111C), VA Greater Los Angeles Health Care System, CURE: VA/UCLA Digestive Diseases Center, Building 115, Room 316, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA.
Curr Gastroenterol Rep. 1999 Dec;1(6):511-7. doi: 10.1007/s11894-999-0012-8.
Zollinger-Ellison syndrome (ZES) is caused by a tumor that secretes gastrin and is the most common of the malignant islet cell tumors. ZES leads to hypergastrinemia, which, in turn, causes an overproduction of gastric acid and results in complications of peptic ulcer disease. Of all the islet cell tumors, gastrinoma tumors have undergone the most extensive study, providing a model of tumor management. Increased awareness and improved biochemical and radiologic techniques mean that these disorders are being recognized in more patients. Advances in the management of gastric acid secretion and new localization methods have significantly reduced the morbidity and mortality associated with ZES. The use of intravenous proton pump inhibitors such as pantoprazole will make surgical and perioperative management more favorable for patients. Radiologic and nuclear medicine studies permit the detection of the majority of islet cell tumors and improve the ability for surgical resection. With the recent cloning of the gene for multiple endocrine neoplasia type I (MEN-I) and the recognition of tumor markers associated with the development of islet cell tumors, early detection of these tumors may someday be possible.
佐林格 - 埃利森综合征（ZES）由分泌胃泌素的肿瘤引起，是最常见的恶性胰岛细胞瘤。ZES导致高胃泌素血症，进而引起胃酸过度分泌，导致消化性溃疡病并发症。在所有胰岛细胞瘤中，胃泌素瘤的研究最为广泛，为肿瘤管理提供了一个模型。认识的提高以及生化和放射学技术的改进意味着更多患者被诊断出患有这些疾病。胃酸分泌管理的进展和新的定位方法显著降低了与ZES相关的发病率和死亡率。使用静脉注射质子泵抑制剂如泮托拉唑将使手术和围手术期管理对患者更为有利。放射学和核医学研究能够检测出大多数胰岛细胞瘤，并提高手术切除的成功率。随着最近多发性内分泌腺瘤I型（MEN - I）基因的克隆以及与胰岛细胞瘤发生相关的肿瘤标志物的发现，这些肿瘤的早期检测有朝一日可能成为现实。
