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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Naruse S, Suzuki A, Ishiguro H, Kitagawa M, Ko S B, Yoshikawa T, Yamamoto A, Hamada H, Hayakawa T

Internal Medicine II, Nagoya University School of Medicine, Japan.

J Korean Med Sci. 2000 Aug;15 Suppl(Suppl):S27-8. doi: 10.3346/jkms.2000.15.S.S27.

5-HT inhibits spontaneous fluid secretion as well as stimulated secretion with secretin (cAMP mediated) or ACh (Ca2+ mediated) in the isolated guinea pig pancreatic ducts. 2. The inhibitory effect of 5-HT is reversible and is dependent on the concentration in the range 0.01-0.1 microM, which is much lower than those that affect intestinal motility and secretion. 3. The 5-HT3 receptor in duct cells appears to mediate the inhibitory effect of 5-HT. 4. [Ca2+]i is unlikely to mediate the inhibitory effect of 5-HT.

5-羟色胺（5-HT）可抑制豚鼠离体胰管的自发性液体分泌以及由促胰液素（cAMP介导）或乙酰胆碱（Ca2+介导）刺激引起的分泌。2. 5-HT的抑制作用是可逆的，且依赖于0.01 - 0.1微摩尔范围内的浓度，该浓度远低于影响肠道运动和分泌的浓度。3. 导管细胞中的5-HT3受体似乎介导了5-HT的抑制作用。4. 细胞内钙离子浓度（[Ca2+]i）不太可能介导5-HT的抑制作用。

Naruse S, Suzuki A, Ishiguro H, Kitagawa M, Ko S B, Yoshikawa T, Yamamoto A, Hamada H, Hayakawa T

Internal Medicine II, Nagoya University School of Medicine, Japan.

J Korean Med Sci. 2000 Aug;15 Suppl(Suppl):S27-8. doi: 10.3346/jkms.2000.15.S.S27.

5-HT inhibits spontaneous fluid secretion as well as stimulated secretion with secretin (cAMP mediated) or ACh (Ca2+ mediated) in the isolated guinea pig pancreatic ducts. 2. The inhibitory effect of 5-HT is reversible and is dependent on the concentration in the range 0.01-0.1 microM, which is much lower than those that affect intestinal motility and secretion. 3. The 5-HT3 receptor in duct cells appears to mediate the inhibitory effect of 5-HT. 4. [Ca2+]i is unlikely to mediate the inhibitory effect of 5-HT.

5-羟色胺（5-HT）可抑制豚鼠离体胰管的自发性液体分泌以及由促胰液素（cAMP介导）或乙酰胆碱（Ca2+介导）刺激引起的分泌。2. 5-HT的抑制作用是可逆的，且依赖于0.01 - 0.1微摩尔范围内的浓度，该浓度远低于影响肠道运动和分泌的浓度。3. 导管细胞中的5-HT3受体似乎介导了5-HT的抑制作用。4. 细胞内钙离子浓度（[Ca2+]i）不太可能介导5-HT的抑制作用。