Serotonin and pancreatic duct function.
作者信息
Naruse S, Suzuki A, Ishiguro H, Kitagawa M, Ko S B, Yoshikawa T, Yamamoto A, Hamada H, Hayakawa T
机构信息
Internal Medicine II, Nagoya University School of Medicine, Japan.
出版信息
J Korean Med Sci. 2000 Aug;15 Suppl(Suppl):S27-8. doi: 10.3346/jkms.2000.15.S.S27.
Abstract
- 5-HT inhibits spontaneous fluid secretion as well as stimulated secretion with secretin (cAMP mediated) or ACh (Ca2+ mediated) in the isolated guinea pig pancreatic ducts. 2. The inhibitory effect of 5-HT is reversible and is dependent on the concentration in the range 0.01-0.1 microM, which is much lower than those that affect intestinal motility and secretion. 3. The 5-HT3 receptor in duct cells appears to mediate the inhibitory effect of 5-HT. 4. [Ca2+]i is unlikely to mediate the inhibitory effect of 5-HT.
摘要
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