Censi F, Calcagnini G, Lino S, Seydnejad S R, Kitney R I, Cerutti S
Department of Computer and Systems Science, La Sapienza, University of Rome, Italy.
Med Biol Eng Comput. 2000 Jul;38(4):416-26. doi: 10.1007/BF02345011.
The interactions between respiration, heart rate and blood pressure variability (HRV, BPV), are considered to be of paramount importance for the study of the functional organisation of the autonomic nervous system (ANS). The aim of the reported study is to detect and classify the intermittent phase locking (PL) phenomena between respiration, HRV and BPV during cardiorespiratory synchronisation experiments, by using the following time-domain techniques: Poincaré maps, recurrence plots, time-space separation plots and frequency tracking locus. The experimental protocol consists of three stages, with normal subjects in paced breathing at 15, 12 and 8 breaths min-1. Transient phenomena of coordination between respiration and the major rhythms of HRV and BPV (low and high frequency, LF and HF) have been detected and classified: no interaction between LF and HF rhythms at 15 breaths min-1; short time intervals of stable 1:2 frequency and phase synchronisation during the 12 breaths min-1 stage; 1:1 PL during the 8 breaths min-1 stage. 1:1 and 1:2 PL phenomena occurred when the respiration frequency was quite close to the LF frequency or when it was about twice the LF frequency, respectively. The complex organisation of the ANS seems to provoke transient rather than permanent PL phenomena between the co-ordinating components of respiration and cardiovascular variability series.
呼吸、心率与血压变异性（HRV、BPV）之间的相互作用，被认为对于自主神经系统（ANS）功能组织的研究至关重要。本报告研究的目的是，通过使用以下时域技术：庞加莱图、递归图、时空分离图和频率跟踪轨迹，在心肺同步实验期间检测并分类呼吸、HRV和BPV之间的间歇性锁相（PL）现象。实验方案包括三个阶段，正常受试者以每分钟15次、12次和8次呼吸的频率进行定频呼吸。已检测并分类了呼吸与HRV和BPV的主要节律（低频和高频，LF和HF）之间的瞬时协调现象：在每分钟15次呼吸时，LF和HF节律之间无相互作用；在每分钟12次呼吸阶段，存在稳定的1:2频率和相位同步的短时间间隔；在每分钟8次呼吸阶段，存在1:1 PL。当呼吸频率分别非常接近LF频率或约为LF频率的两倍时，会出现1:1和1:2 PL现象。ANS的复杂组织似乎会在呼吸与心血管变异性系列的协调成分之间引发瞬时而非永久的PL现象。
