• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

箭叶淫羊藿中的黄酮醇苷及其对PC12h细胞的神经突生长活性。

Flavonol glycosides from Epimedium sagittatum and their neurite outgrowth activity on PC12h cells.

作者信息

Kuroda M, Mimaki Y, Sashida Y, Umegaki E, Yamazaki M, Chiba K, Mohri T, Kitahara M, Yasuda A, Naoi N, Xu Z W, Li M R

出版信息

Planta Med. 2000 Aug;66(6):575-7. doi: 10.1055/s-2000-8611.

DOI:10.1055/s-2000-8611
PMID:10985091
Abstract

The MeOH extract of Epimedium sagittatum was found to show neurite outgrowth activity on cultured PC12h cells. Bioassay-guided fractionation of the MeOH extract yielded six prenylated flavonol glycosides, ikarisoside A (1), icarisid II (2), epimedoside A (3), icariin (4), epimedin B (5), and epimedokoreanoside-I (6) as the active ingredients.

摘要

淫羊藿甲醇提取物对培养的PC12h细胞具有神经突生长活性。对淫羊藿甲醇提取物进行生物活性导向分离,得到6种异戊烯基黄酮醇苷,分别为淫羊藿苷A(1)、淫羊藿苷II(2)、朝藿定A(3)、淫羊藿苷(4)、朝藿定B(5)和朝鲜淫羊藿苷-I(6)作为活性成分。

相似文献

1
Flavonol glycosides from Epimedium sagittatum and their neurite outgrowth activity on PC12h cells.箭叶淫羊藿中的黄酮醇苷及其对PC12h细胞的神经突生长活性。
Planta Med. 2000 Aug;66(6):575-7. doi: 10.1055/s-2000-8611.
2
Acetylated flavonoid glycosides potentiating NGF action from Scoparia dulcis.来自甜地丁的乙酰化黄酮苷增强神经生长因子作用。
J Nat Prod. 2004 Apr;67(4):725-7. doi: 10.1021/np0302908.
3
Two new flavonol glycosides from Epimedium koreanum Nakai.朝鲜淫羊藿中的两种新黄酮醇苷。
J Asian Nat Prod Res. 2009;11(5):401-9. doi: 10.1080/10286020902867151.
4
[Chemical constituents of Epimedium acuminatum Franch. (II)].尖叶淫羊藿的化学成分(II)
Zhongguo Zhong Yao Za Zhi. 1998 Dec;23(12):737-9, 765.
5
Effects of total flavonoids and flavonol glycosides from Epimedium koreanum Nakai on the proliferation and differentiation of primary osteoblasts.朝鲜淫羊藿总黄酮及黄酮醇苷对原代成骨细胞增殖与分化的影响
Phytomedicine. 2008 Jan;15(1-2):55-61. doi: 10.1016/j.phymed.2007.04.002. Epub 2007 May 4.
6
Prenylflavonol, acylated flavonol glycosides and related compounds from Epimedium sagittatum.箭叶淫羊藿中的异戊烯基黄酮醇、酰化黄酮醇苷及相关化合物。
Phytochemistry. 2007 Oct;68(19):2455-64. doi: 10.1016/j.phytochem.2007.05.035. Epub 2007 Jul 5.
7
Isolation and immunomodulatory effect of flavonol glycosides from Epimedium hunanense.
Planta Med. 1997 Aug;63(4):316-9. doi: 10.1055/s-2006-957690.
8
Flavonoids from Epimedium wanshanense.来自梵净山淫羊藿的黄酮类化合物。
Phytochemistry. 1996 Sep;43(2):527-30. doi: 10.1016/0031-9422(96)00187-2.
9
Chemotypic and genetic diversity in Epimedium sagittatum from different geographical regions of China.中国不同地理区域箭叶淫羊藿的化学型和遗传多样性
Phytochemistry. 2015 Aug;116:180-187. doi: 10.1016/j.phytochem.2015.04.005. Epub 2015 Apr 30.
10
Clerodane diterpenoids with NGF-potentiating activity from Ptychopetalum olacoides.来自椭圆叶翅子树的具有增强神经生长因子活性的克罗烷二萜类化合物。
J Nat Prod. 2008 Oct;71(10):1760-3. doi: 10.1021/np8004002. Epub 2008 Sep 27.

引用本文的文献

1
Transcriptomic and metabolomic analysis reveals the difference between large and small flower taxa of Herba Epimedii during flavonoid accumulation.转录组学和代谢组学分析揭示了淫羊藿黄酮积累过程中大花类群和小花类群之间的差异。
Sci Rep. 2022 Feb 17;12(1):2762. doi: 10.1038/s41598-022-06761-z.
2
Icariin, an Up-and-Coming Bioactive Compound Against Neurological Diseases: Network Pharmacology-Based Study and Literature Review.淫羊藿素:一种有前途的神经疾病防治生物活性化合物:基于网络药理学的研究和文献综述。
Drug Des Devel Ther. 2021 Aug 20;15:3619-3641. doi: 10.2147/DDDT.S310686. eCollection 2021.
3
Ikarisoside A inhibits acetylcholine-induced catecholamine secretion and synthesis by suppressing nicotinic acetylcholine receptor-ion channels in cultured bovine adrenal medullary cells.
淫羊藿苷A通过抑制培养的牛肾上腺髓质细胞中的烟碱型乙酰胆碱受体离子通道,抑制乙酰胆碱诱导的儿茶酚胺分泌和合成。
Naunyn Schmiedebergs Arch Pharmacol. 2015 Dec;388(12):1259-69. doi: 10.1007/s00210-015-1161-y. Epub 2015 Aug 11.
4
Improvement of kidney yang syndrome by icariin through regulating hypothalamus-pituitary-adrenal axis.淫羊藿苷通过调节下丘脑 - 垂体 - 肾上腺轴改善肾阳虚证。
Chin J Integr Med. 2015 Oct;21(10):765-71. doi: 10.1007/s11655-015-2063-z. Epub 2015 Mar 31.
5
Icariin induces synoviolin expression through NFE2L1 to protect neurons from ER stress-induced apoptosis.淫羊藿苷通过NFE2L1诱导滑膜素表达,以保护神经元免受内质网应激诱导的凋亡。
PLoS One. 2015 Mar 25;10(3):e0119955. doi: 10.1371/journal.pone.0119955. eCollection 2015.
6
Icariin ameliorates neuropathological changes, TGF-β1 accumulation and behavioral deficits in a mouse model of cerebral amyloidosis.淫羊藿苷改善脑淀粉样变性小鼠模型的神经病理变化、转化生长因子-β1蓄积及行为缺陷。
PLoS One. 2014 Aug 7;9(8):e104616. doi: 10.1371/journal.pone.0104616. eCollection 2014.