Hartley T, Burgess N, Lever C, Cacucci F, O'Keefe J
Institute of Cognitive Neuroscience, University College London, UK.
Hippocampus. 2000;10(4):369-79. doi: 10.1002/1098-1063(2000)10:4<369::AID-HIPO3>3.0.CO;2-0.
A model of place-cell firing is presented that makes quantitative predictions about specific place cells' spatial receptive fields following changes to the rat's environment. A place cell's firing rate is modeled as a function of the rat's location by the thresholded sum of the firing rates of a number of putative cortical inputs. These inputs are tuned to respond whenever an environmental boundary is at a particular distance and allocentric direction from the rat. The initial behavior of a place cell in any environment is simply determined by its set of inputs and its threshold; learning is not necessary. The model is shown to produce a good fit to the firing of individual place cells, and populations of place cells across environments of differing shape. The cells' behavior can be predicted for novel environments of arbitrary size and shape, or for manipulations such as introducing a barrier. The model can be extended to make behavioral predictions regarding spatial memory.
提出了一种位置细胞放电模型，该模型可对大鼠环境变化后特定位置细胞的空间感受野进行定量预测。位置细胞的放电率通过一些假定的皮质输入的放电率的阈值总和，被建模为大鼠位置的函数。这些输入被调整为每当环境边界处于距大鼠特定距离和以体为中心的方向时作出反应。在任何环境中，位置细胞的初始行为仅由其输入集及其阈值决定；无需学习。该模型被证明能很好地拟合单个位置细胞的放电情况，以及不同形状环境中的位置细胞群体。对于任意大小和形状的新环境，或对于诸如引入障碍物等操作，细胞的行为都可以被预测。该模型可以扩展以做出关于空间记忆的行为预测。
