Bennett Lauren, de Cothi William, Muessig Laurenz, Rodrigues Fábio R, Cacucci Francesca, Wills Tom J, Sun Yanjun, Giocomo Lisa M, Lever Colin, Poulter Steven, Barry Caswell
Department of Cell and Developmental Biology, University College London, London, UK.
Department of Neuroscience, Physiology & Pharmacology, University College London, London, UK.
bioRxiv. 2024 Nov 7:2024.11.06.622306. doi: 10.1101/2024.11.06.622306.
The successor representation has emerged as a powerful model for understanding mammalian navigation and memory; explaining the spatial coding properties of hippocampal place cells and entorhinal grid cells. However, the diverse spatial responses of subicular neurons, the primary output of the hippocampus, have eluded a unified account. Here, we demonstrate that incorporating rodent behavioural biases into the successor representation successfully reproduces the heterogeneous activity patterns of subicular neurons. This framework accounts for the emergence of boundary and corner cells; neuronal types absent in upstream hippocampal regions. We provide evidence that subicular firing patterns are more accurately described by the successor representation than a purely spatial or boundary vector cell model of subiculum. Our work offers a unifying theory of subicular function that positions the subiculum, more than other hippocampal regions, as a predictive map of the environment.
后继表征已成为理解哺乳动物导航和记忆的强大模型；它解释了海马体位置细胞和内嗅皮层网格细胞的空间编码特性。然而，海马体主要输出区域——下托神经元的多样空间反应，却一直未能得到统一的解释。在这里，我们证明，将啮齿动物的行为偏差纳入后继表征，能够成功再现下托神经元的异质性活动模式。该框架解释了边界细胞和角落细胞的出现；这些神经元类型在上游海马区域中并不存在。我们提供的证据表明，与下托的纯空间或边界向量细胞模型相比，后继表征能更准确地描述下托的放电模式。我们的研究提出了一种关于下托功能的统一理论，该理论认为，与其他海马区域相比，下托更是环境的预测地图。
