Bersani G, Iannitelli A, Fiore M, Angelucci F, Aloe L
3rd Psychiatric Clinic, 'La Sapienza' University of Rome, Italy.
Med Hypotheses. 2000 Sep;55(3):199-207. doi: 10.1054/mehy.1999.1044.
Nerve growth factor (NGF) was discovered and characterized for its role on the growth, differentiation and maintenance of specific neurons of the peripheral nervous system. Subsequent studies revealed that NGF is synthesized and released within the central nervous system and exerts a trophic and functional role on basal forebrain cholinergic neurons; it is involved in a protective role following brain insults induced by an epileptic status, seizure, as well as surgical and chemical lesions.More recently our collaborative studies provided evidence that NGF is implicated in neurobehavioral response including cerebral alterations associated with psychiatric disorders. In this brief review, ongoing and emerging data are presented and discussed.
神经生长因子（NGF）因其对周围神经系统特定神经元的生长、分化和维持作用而被发现和表征。随后的研究表明，NGF在中枢神经系统内合成并释放，对基底前脑胆碱能神经元发挥营养和功能作用；它在癫痫持续状态、癫痫发作以及手术和化学损伤引起的脑损伤后起到保护作用。最近，我们的合作研究提供了证据，表明NGF与神经行为反应有关，包括与精神疾病相关的大脑改变。在这篇简短的综述中，将展示和讨论正在进行的和新出现的数据。
