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成年去胸腺、致死性照射并经骨髓重建小鼠B细胞群体的恢复情况。

The recovery of the B-cell population in adult thymectomized, lethally irradiated and bone marrow-reconstituted mice.

作者信息

van Muiswinkel W B, van Beek J J, van Soest P L

出版信息

Immunology. 1975 Aug;29(2):327-36.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1445937/

Abstract

The recovery of the B-cell population in adult thymectomized, irradiated and bone marrow-reconstituted mice (T X BM mice was estimated at various times after bone marrow transplantation. The spleen cells to be tested were mixed with dexamethasone-resistant thymocytes (DRT) and sheep red blood cells (SRBC) and transferrred to irradiated recipients. The number of plaque-forming cells (PFC) in the spleen of the recipients was determined 7 days later. Using this functional B-cell assay a sequential appearance of the precursors of IgM-, IgG- and IgA-PFC in the spleen of T X BM mice was observed. The precursors of IgM-PFG (IgM-B cells) were present immediately after transplantation. The first IgG-B cells could be detected at 13-16 days after transplantation and the IgA-B cells finally appeared at 22 days after transplantation. The number of B cells reached a constant and normal level at 30 days after transplantation. The IgM-, IgG- and IgA-B cell development in sham-thymectomized, irradiated and bone narrow-reconstituted mice (ST X BM mice) was virtually the same as in T X BM mice.

摘要

在对成年小鼠进行胸腺切除、照射并进行骨髓重建（TX BM小鼠）后，于骨髓移植后的不同时间点评估B细胞群体的恢复情况。将待检测的脾细胞与地塞米松抗性胸腺细胞（DRT）及绵羊红细胞（SRBC）混合，然后转移至经照射的受体小鼠体内。7天后测定受体小鼠脾脏中形成空斑细胞（PFC）的数量。利用这种功能性B细胞检测方法，观察到TX BM小鼠脾脏中IgM -、IgG -和IgA - PFC前体细胞的相继出现。移植后即刻就存在IgM - PFG（IgM - B细胞）的前体细胞。首次检测到IgG - B细胞是在移植后13 - 16天，而IgA - B细胞最终在移植后22天出现。移植后30天，B细胞数量达到稳定且正常的水平。假胸腺切除、照射并进行骨髓重建的小鼠（ST X BM小鼠）中IgM -、IgG -和IgA - B细胞的发育情况与TX BM小鼠基本相同。