van Muiswinkel W B, de Laat A M, Mink J G, van Oudenaren A, Benner R
Int Arch Allergy Appl Immunol. 1979;60(3):240-8.
A comparison was made between the serum immunoglobulin (Ig) levels in H-2 compatible AKR and C3H mice. The IgG1 and especially the IgA level in preleukemic AKR mice was much lower than in age-matched C3H mice, while the IgM concentration was hardly different for AKR and C3H. Lethally irradiated AKR and C3H mice reconstituted with syngeneic bone marrow (BM) cells showed a return to serum Ig levels which are normal for these strains. In AKR mice reconstituted with C3H BM cells low IgA levels were observed. On the other hand, in C3H mice reconstituted with AKR BM cells high quantities of IgA appeared, showing the AKR allotype. It is concluded that the low serum IgA concentration in AKR mice is not a reflection of a genetically determined inability of the B cell line to produce IgA, but rather a manifestation of a genetically determined capability to prevent IgA synthesis.
对H-2相容的AKR和C3H小鼠的血清免疫球蛋白（Ig）水平进行了比较。白血病前期AKR小鼠的IgG1水平，尤其是IgA水平，远低于年龄匹配的C3H小鼠，而AKR和C3H小鼠的IgM浓度几乎没有差异。用同基因骨髓（BM）细胞重建的经致死剂量照射的AKR和C3H小鼠，其血清Ig水平恢复到这些品系的正常水平。在用C3H BM细胞重建的AKR小鼠中，观察到IgA水平较低。另一方面，在用AKR BM细胞重建的C3H小鼠中，出现了大量显示AKR同种异型的IgA。得出的结论是，AKR小鼠血清IgA浓度低并非反映B细胞系在遗传上无法产生IgA，而是反映了在遗传上具有阻止IgA合成的能力。
