Amoura Z, Koutouzov S, Piette J C
Service de Médecine Interne, Hôpital Pitié-Salpêtrière, Paris, France.
Curr Opin Rheumatol. 2000 Sep;12(5):369-73. doi: 10.1097/00002281-200009000-00003.
Nucleosomes play a central role in the antinuclear antibody response in lupus. Lupus anti-dsDNA and antihistone antibodies directed toward nucleosomes belong together with nucleosome-specific antibodies, to a broad antinucleosome antibody family. Besides anti-dsDNA, nucleosome-specific antibodies have a major role in the pathophysiology of systemic lupus erythematosus (SLE) and emphasize the role of nucleosome-antinucleosome immune complexes. Antinucleosome immunoglobulin G antibodies are a more sensitive marker of SLE than anti-dsDNA, and are almost exclusively found in lupus, scleroderma, and mixed connective tissue diseases. An understanding of the key role of the nucleosome will likely make possible new therapeutic interventions in SLE, such as a tolerance induction to the subnucleosomal particles.
核小体在狼疮的抗核抗体反应中起核心作用。针对核小体的狼疮抗双链DNA和抗组蛋白抗体与核小体特异性抗体一起，属于一个广泛的抗核小体抗体家族。除了抗双链DNA外，核小体特异性抗体在系统性红斑狼疮（SLE）的病理生理学中起主要作用，并强调了核小体-抗核小体免疫复合物的作用。抗核小体免疫球蛋白G抗体是SLE比抗双链DNA更敏感的标志物，几乎仅见于狼疮、硬皮病和混合性结缔组织病。了解核小体的关键作用可能会使SLE的新治疗干预成为可能，例如对亚核小体颗粒的耐受性诱导。
