一种从芳基/烷基硫代糖苷方便地制备糖基氯的方法。

A convenient preparation of glycosyl chlorides from aryl/alkyl thioglycosides.

作者信息

Sugiyama S, Diakur J M

机构信息

Faculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, Edmonton, Canada.

出版信息

Org Lett. 2000 Aug 24;2(17):2713-5. doi: 10.1021/ol0063050.

DOI:10.1021/ol0063050

PMID:10990435

Abstract

[reaction: see text]Because of the vast structural diversity encountered in the field of glycobiology, versatile methods for orthogonal oligosaccharide assembly are always of interest. Reported herein is the preparation of glycosyl chloride donors obtained by reaction of the corresponding thioglycoside precursors with chlorosulfonium chloride reagent 4. The crude chlorides thus obtained can be used directly in subsequent glycosylation reactions, and examples of the generality of this approach are provided.

摘要

[反应：见正文]由于在糖生物学领域遇到的巨大结构多样性，用于正交寡糖组装的通用方法一直备受关注。本文报道了通过相应的硫代糖苷前体与氯锍氯化物试剂4反应获得的糖基氯供体的制备。由此得到的粗氯化物可直接用于后续的糖基化反应，并提供了该方法通用性的实例。