Bechtel J, Boring J R
Am J Clin Pathol. 1979 Jan;71(1):93-6. doi: 10.1093/ajcp/71.1.93.
Most clinical isolates of Yersinia enterocolitica have been reported to be inhibited by a wide variety of antimicrobial agents. This finding indicates that Y. enterocolitica infrequently acquires resistance by gene transfer from other bacteria in nature. In the present study the authors examined whether Y. enterocolitica has the potential for acquiring antibiotic resistance from another organism in vitro. Mixed cultures of multiple-antibiotic-resistant Escherichia coli and a sensitive Y. enterocolitica yielded resistant Y. enterocolitica. Resistance to at least four drugs was transferred at a frequency of approximately 10(-7) transconjugants per donor. The newly resistant Y. enterocolitica transferred resistance to a sensitive E. coli at a slightly higher frequency. Resistance to at least one antibiotic was transferred to all five strains of Y. enterocolitica tested.
据报道，大多数小肠结肠炎耶尔森菌临床分离株会受到多种抗菌剂的抑制。这一发现表明，小肠结肠炎耶尔森菌在自然环境中很少通过从其他细菌进行基因转移来获得耐药性。在本研究中，作者检测了小肠结肠炎耶尔森菌在体外是否有从其他生物体获得抗生素耐药性的可能性。多重耐药大肠杆菌与敏感小肠结肠炎耶尔森菌的混合培养产生了耐药的小肠结肠炎耶尔森菌。对至少四种药物的耐药性以大约每供体10(-7)个转接合子的频率进行转移。新产生耐药性的小肠结肠炎耶尔森菌以略高的频率将耐药性转移给敏感大肠杆菌。对至少一种抗生素的耐药性被转移到了所测试的所有五株小肠结肠炎耶尔森菌中。
