Morohashi A, Satake M, Oshima Y, Yasumoto T
Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
Biosci Biotechnol Biochem. 2000 Aug;64(8):1761-3. doi: 10.1271/bbb.64.1761.
The marine polyether toxin, 45-hydroxyyessotoxin, was isolated together with yessotoxin from the scallop, Patinopecten yessoensis. The 45-hydroxy group in the side chain was esterified with (S)- and (R)-alpha-methoxyalpha-trifluoromethylphenylacetic acids (MTPA). A detailed analysis of the 2D NMR spectra of the two esters established the R configuration at C45.
从虾夷扇贝（Patinopecten yessoensis）中分离出海洋聚醚毒素45-羟基岩沙海葵毒素，同时还分离出了岩沙海葵毒素。侧链上的45-羟基与（S）-和（R）-α-甲氧基-α-三氟甲基苯乙酸（MTPA）发生酯化反应。对这两种酯的二维核磁共振谱进行详细分析，确定了C45处的R构型。
