Terao K, Ito E, Oarada M, Murata M, Yasumoto T
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.
Toxicon. 1990;28(9):1095-104. doi: 10.1016/0041-0101(90)90148-z.
The histopathological response of male ICR mice to yessotoxin, isolated from the digestive organ of scallops Patinopecten yessoensis, was compared with that of desulfated yessotoxin. The target organ of the former was the heart and those of the latter were the liver and pancreas. Electron microscopically, marked intracytoplasmic edema in cardiac muscle cells was seen within 3 hr after the i.p. injection of over 300 micrograms/kg of yessotoxin. In contrast, desulfated yessotoxin at the same dose caused within 24 hr of i.p. injection severe fatty degeneration and intracellular necrosis in the liver and pancreas but not in the heart. Biochemically, the content of triglycerides in the liver of mice treated with desulfated yessotoxin increased about 60 times, and phospholipids two-fold more than the control levels of those of mice treated with yessotoxin.
将从虾夷扇贝消化器官中分离出的岩沙海葵毒素对雄性ICR小鼠的组织病理学反应与脱硫岩沙海葵毒素的反应进行了比较。前者的靶器官是心脏，后者的靶器官是肝脏和胰腺。在电子显微镜下，腹腔注射超过300微克/千克岩沙海葵毒素后3小时内，可见心肌细胞内明显的胞浆水肿。相比之下，相同剂量的脱硫岩沙海葵毒素腹腔注射后24小时内，会导致肝脏和胰腺出现严重的脂肪变性和细胞内坏死，但心脏未出现这种情况。生化分析表明，用脱硫岩沙海葵毒素处理的小鼠肝脏中甘油三酯含量增加了约60倍，磷脂含量比用岩沙海葵毒素处理的小鼠对照水平增加了两倍。
