Ishikawa Y, Asuwa N, Ishii T, Ito K, Akasaka Y, Masuda T, Zhang L, Kiguchi H
Department of Pathology, Toho University School of Medicine, Tokyo, Japan.
Virchows Arch. 2000 Aug;437(2):138-48. doi: 10.1007/s004280000200.
The collagen alterations in the vascular wall remodeled by hemodynamic change were investigated by electron microscopy and immunohistochemistry. The left anterior descending coronary artery (LAD) without a myocardial bridge (MB) showed both lower matrix metalloproteinase-1 (MMP-1) expression and a smaller extent of spiraled collagen (SC) distribution than the LAD wall with MB, in which the intima was influenced by high shear stress. In the wall of the varicose great saphenous vein (GSV) the expression of MMP-1 was lower, while the expression of prolyl 4-hydroxylase was higher, than in the normal GSV. The extent of SC distribution in the intima and media of the varicose GSV was smaller than that in the normal GSV. An analogous difference in results was demonstrated between the portal vein (PV) of patients with liver cirrhosis and normal PV. However, the levels of expression of MMP-2, MMP-9 and tissue inhibitors of MMP (TIMPs) in these pathologic vessels were not different from those in the corresponding normal vessels. The results indicate that hemodynamic forces such as shear stress and increased intravascular blood pressure contribute to the collagen alterations in the vascular wall, which may lead to vascular wall remodeling.
通过电子显微镜和免疫组织化学研究了由血流动力学变化重塑的血管壁中的胶原改变。与存在心肌桥（MB）的左前降支冠状动脉（LAD）壁相比，没有心肌桥的LAD壁显示出较低的基质金属蛋白酶-1（MMP-1）表达和较小范围的螺旋状胶原（SC）分布，其中内膜受到高剪切应力的影响。与正常大隐静脉（GSV）相比，曲张大隐静脉（GSV）壁中MMP-1的表达较低，而脯氨酰4-羟化酶的表达较高。曲张GSV内膜和中膜中SC分布的范围小于正常GSV。在肝硬化患者的门静脉（PV）和正常PV之间也显示出类似的结果差异。然而，这些病理性血管中MMP-2、MMP-9和基质金属蛋白酶组织抑制剂（TIMPs）的表达水平与相应正常血管中的表达水平没有差异。结果表明，诸如剪切应力和血管内血压升高等血流动力学力导致血管壁中的胶原改变，这可能导致血管壁重塑。
