Korolev P N, Bulgakova V G, Polin A N, Melikhova E I, Silaev A B
Mikrobiologiia. 1975 May-Jun;44(3):400-3.
Heliomycin at a concentration of 100 mcg/ml had almost no effect on the growth of Escherichia coli, which was inhibited only upon the combined action of heliomycin and ethanol that facilitated the penetration of the antibiotic into the cell. Heliomycin inhibited in these conditions the synthesis of RNA and had no effect on the synthesis of DNA in the three studied strains of E. coli. The synthesis of protein either was not inhibited by heliomycin at all or was inhibited only to a small extent.
浓度为100微克/毫升的日光霉素对大肠杆菌的生长几乎没有影响，只有在日光霉素和乙醇共同作用时才会抑制其生长，乙醇可促进抗生素进入细胞。在这些条件下，日光霉素抑制了RNA的合成，对所研究的三株大肠杆菌的DNA合成没有影响。蛋白质的合成要么根本不受日光霉素抑制，要么仅受到轻微抑制。
