Belizhenko V D
Antibiotiki. 1979 Jan;24(1):42-5.
The effect of tetracycline combination with sodium desoxycholate, a surface-active substance, on the synthesis of proteins and nucleic acids in the cells of NAG-vibrio, Staph. aureus and E. coli was studied by incorporation of 1-14C-glycine and 8-14C-adenine into proteins and nucleic acids. It was found that sodium desoxycholate suppressed the synthesis of proteins and nucleic acids in the cells of NAG-vibrio and Staph. aureus. Its combination with tetracycline resulted in summation or increase of the suppressive effects on proteins and nucleic acids as compared to the effect of the substances used alone. Sodium desoxycholate even in very high concentration, up to 12800 gamma/ml, had no effect on the synthesis of proteins and nucleic acids in the cells of E. coli and respectively it did not change the activity of tetracycline on combined use.
通过将1-¹⁴C-甘氨酸和8-¹⁴C-腺嘌呤掺入蛋白质和核酸中，研究了四环素与表面活性物质去氧胆酸钠联合使用对NAG弧菌、金黄色葡萄球菌和大肠杆菌细胞中蛋白质和核酸合成的影响。结果发现，去氧胆酸钠抑制了NAG弧菌和金黄色葡萄球菌细胞中蛋白质和核酸的合成。与单独使用这些物质的效果相比，它与四环素联合使用对蛋白质和核酸的抑制作用产生了相加或增强的效果。即使浓度高达12800微克/毫升，去氧胆酸钠对大肠杆菌细胞中蛋白质和核酸的合成也没有影响，并且在联合使用时它也不会改变四环素的活性。
