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本文引用的文献

1
Tissue-specific regulation of vein/EGF receptor signaling in Drosophila.果蝇中静脉/表皮生长因子受体信号的组织特异性调控。
Dev Biol. 1999 Dec 1;216(1):243-59. doi: 10.1006/dbio.1999.9459.
2
Fringe, Notch, and making developmental boundaries.边缘系统、Notch信号通路与发育边界的形成
Curr Opin Genet Dev. 1999 Aug;9(4):434-41. doi: 10.1016/S0959-437X(99)80066-5.
3
Compartment boundaries: at the edge of development.
Trends Genet. 1999 Aug;15(8):320-6. doi: 10.1016/s0168-9525(99)01774-6.
4
The Iroquois homeodomain proteins are required to specify body wall identity in Drosophila.易洛魁同源域蛋白是果蝇中确定体壁特征所必需的。
Genes Dev. 1999 Jul 1;13(13):1754-61. doi: 10.1101/gad.13.13.1754.
5
Hedgehog activates the EGF receptor pathway during Drosophila head development.
Development. 1999 Jun;126(12):2623-30. doi: 10.1242/dev.126.12.2623.
6
Vein expression is induced by the EGF receptor pathway to provide a positive feedback loop in patterning the Drosophila embryonic ventral ectoderm.静脉表达由表皮生长因子受体途径诱导产生，以在果蝇胚胎腹侧外胚层模式形成过程中提供一个正反馈回路。
Genes Dev. 1999 Jan 15;13(2):158-62. doi: 10.1101/gad.13.2.158.
7
Roles of transforming growth factor-alpha and epidermal growth factor in chick limb development.转化生长因子-α和表皮生长因子在鸡胚肢体发育中的作用。
Dev Biol. 1998 Oct 1;202(1):43-55. doi: 10.1006/dbio.1998.8988.
8
Lhx2, a vertebrate homologue of apterous, regulates vertebrate limb outgrowth.Lhx2是apterous的脊椎动物同源物，可调节脊椎动物肢体的生长。
Development. 1998 Oct;125(20):3925-34. doi: 10.1242/dev.125.20.3925.
9
EGF domain swap converts a drosophila EGF receptor activator into an inhibitor.表皮生长因子结构域交换将一种果蝇表皮生长因子受体激活剂转变为抑制剂。
Genes Dev. 1998 Apr 1;12(7):908-13. doi: 10.1101/gad.12.7.908.
10
Different spatial and temporal interactions between Notch, wingless, and vestigial specify proximal and distal pattern elements of the wing in Drosophila.Notch、无翅基因和痕迹基因之间不同的时空相互作用决定了果蝇翅膀的近端和远端模式元素。
Dev Biol. 1998 Feb 15;194(2):196-212. doi: 10.1006/dbio.1997.8829.

果蝇表皮生长因子受体信号通路在早期翅芽发育中的双重作用。

Dual role for Drosophila epidermal growth factor receptor signaling in early wing disc development.

作者信息

Wang S H, Simcox A, Campbell G

机构信息

Department of Molecular Genetics, Ohio State University, Columbus, Ohio 43210, USA.

出版信息

Genes Dev. 2000 Sep 15;14(18):2271-6. doi: 10.1101/gad.827000.

DOI:10.1101/gad.827000
PMID:10995384
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC316934/
Abstract

Cell fate decisions in the early Drosophila wing disc assign cells to compartments (anterior or posterior and dorsal or ventral) and distinguish the future wing from the body wall (notum). Here we show that EGF-receptor (EGFR) signaling stimulated by its ligand, Vein, has a fundamental role in regulating two of these cell fate choices: (1) Vn/EGFR signaling directs cells to become notum by antagonizing wing development and by activating notum-specifying genes; (2) Vn/EGFR signaling directs cells to become part of the dorsal compartment by induction of apterous, the dorsal selector gene, and consequently also controls wing development, which depends on an interaction between dorsal and ventral cells.

摘要

果蝇早期翅盘内的细胞命运决定将细胞分配到不同的区域（前部或后部以及背部或腹部），并区分未来的翅膀与体壁（背板）。我们在此表明，由其配体Vein刺激的表皮生长因子受体（EGFR）信号传导在调节这些细胞命运选择中的两个方面具有基本作用：（1）Vn/EGFR信号传导通过拮抗翅膀发育并激活指定背板的基因，引导细胞成为背板；（2）Vn/EGFR信号传导通过诱导背部选择基因apterous，引导细胞成为背部区域的一部分，因此也控制依赖于背部和腹部细胞之间相互作用的翅膀发育。