Rodriguez-Esteban C, Schwabe J W, Peña J D, Rincon-Limas D E, Magallón J, Botas J, Izpisúa Belmonte J C
Gene Expression Laboratory, The Salk Institute, La Jolla, CA 92037, USA.
Development. 1998 Oct;125(20):3925-34. doi: 10.1242/dev.125.20.3925.
apterous specifies dorsal cell fate and directs outgrowth of the wing during Drosophila wing development. Here we show that, in vertebrates, these functions appear to be performed by two separate proteins. Lmx-1 is necessary and sufficient to specify dorsal identity and Lhx2 regulates limb outgrowth. Our results suggest that Lhx2 is closer to apterous than Lmx-1, yet, in vertebrates, Lhx2 does not specify dorsal cell fate. This implies that in vertebrates, unlike Drosophila, limb outgrowth can be dissociated from the establishment of the dorsoventral axis.
无翅基因在果蝇翅膀发育过程中决定背侧细胞命运并指导翅膀的生长。我们在此表明，在脊椎动物中，这些功能似乎由两种不同的蛋白质来执行。Lmx - 1对于决定背侧特征是必需且充分的，而Lhx2调节肢体的生长。我们的结果表明，Lhx2比Lmx - 1更接近无翅基因，然而，在脊椎动物中，Lhx2并不决定背侧细胞命运。这意味着在脊椎动物中，与果蝇不同，肢体的生长可以与背腹轴的建立相分离。
