de Lacalle S, Saper C B
Department of Neurology and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Neuroscience. 2000;100(1):115-30. doi: 10.1016/s0306-4522(00)00245-1.
Calcitonin gene-related peptide serves as a neuromodulator in several ascending visceral sensory pathways from the parabrachial nucleus to the thalamus, amygdala and the visceral sensory cortex in rats, but these pathways have not been studied in primates. We have examined the distribution of calcitonin gene-related peptide-like immunoreactive innervation of the corresponding areas of the human brain, including the cortex, diencephalon and brainstem. We report the finding of three populations of calcitonin gene-related peptide-like immunoreactive cells that are homologous to those that have been characterized in the rat: the external lateral and external medial parabrachial subnuclei and the posterior intralaminar thalamic complex, including the subparafascicular, lateral subparafascicular and peripeduncular nuclei. In addition, scattered calcitonin gene-related peptide-like immunoreactive cells were found in the periventricular hypothalamus. Calcitonin gene-related peptide-like immunoreactive terminals were found in regions homologous to the projection areas of the external medial and external lateral parabrachial subnuclei in the rat, including the ventroposterior parvicellular nucleus of the thalamus, the central nucleus of the amygdala, the bed nucleus of the stria terminalis and the insular cortex; and in the terminal field of the posterior intralaminar thalamic complex, including the amygdalo-striatal transition region and the insular cortex. These results suggest that, similarly to other species, calcitonin gene-related peptide may also serve as a marker for ascending visceral sensory pathways in the human brain.
降钙素基因相关肽在大鼠从臂旁核到丘脑、杏仁核和内脏感觉皮层的几条上行内脏感觉通路中作为神经调质发挥作用，但这些通路在灵长类动物中尚未得到研究。我们已经研究了人脑相应区域，包括皮层、间脑和脑干中降钙素基因相关肽样免疫反应性神经支配的分布。我们报告发现了三类降钙素基因相关肽样免疫反应性细胞，它们与在大鼠中已被鉴定的细胞同源：外侧臂旁核和内侧臂旁核以及丘脑后内侧核复合体，包括束旁下核、外侧束旁下核和脚周核。此外，在室旁下丘脑发现了散在的降钙素基因相关肽样免疫反应性细胞。在与大鼠内侧臂旁核和外侧臂旁核投射区域同源的区域发现了降钙素基因相关肽样免疫反应性终末，包括丘脑腹后小细胞核、杏仁核中央核、终纹床核和岛叶皮层；以及在丘脑后内侧核复合体的终末场，包括杏仁核-纹状体过渡区和岛叶皮层。这些结果表明，与其他物种类似，降钙素基因相关肽也可能是人脑中上行内脏感觉通路的标志物。
