Sillanaukee P, Koivula T, Jokela H, Pitkäjärvi T, Seppä K
Departments of Clinical Chemistry and Psychiatry, University of Tampere, Medical School and Tampere University Hospital, Tampere, Finland. finnish-immunotech.com
Atherosclerosis. 2000 Oct;152(2):503-10. doi: 10.1016/s0021-9150(00)00369-5.
To study the association of alcohol consumption and lipid-based cardiovascular risk factors among middle-age women, cross-sectional analysis among 274 middle-aged healthy women with different drinking habits and a follow-up analysis of alcoholic women during abstinence was performed. Serum total cholesterol, low and high-density lipoprotein cholesterol (LDL and HDL cholesterol), triglycerides (TG), apolipoproteins A1 (Apo A1) and B (Apo B), and HDL-cholesterol subfractions 2 (HDL(2)) and 3 (HDL(3)) were measured. All lipid values except LDL cholesterol positively correlated with self-reported alcohol consumption. When alcoholics were excluded the correlation was significant only for HDL cholesterol, HDL(3), and Apo A1. The increasing trend of HDL cholesterol, HDL(3) and Apo A1 were clearly seen first in women consuming >20-40 g/day of absolute alcohol. Alcohol consumption >40 g/day increased all lipid values except LDL cholesterol. Abstinence for 2 weeks caused a significant decrease in HDL(3) cholesterol, and an increase in LDL cholesterol and Apo B. The results indicate that among middle-aged women the Apo A1 and HDL cholesterol via its HDL(3) but not HDL(2) subfraction might play a role in the beneficial coronary consequences associated with moderate alcohol consumption. However, the increasing beneficial trend first appears when daily drinking exceeds 20 g/day.
为研究中年女性饮酒与基于血脂的心血管危险因素之间的关联，我们对274名具有不同饮酒习惯的中年健康女性进行了横断面分析，并对戒酒期间的饮酒女性进行了随访分析。测量了血清总胆固醇、低密度和高密度脂蛋白胆固醇（LDL和HDL胆固醇）、甘油三酯（TG）、载脂蛋白A1（Apo A1）和B（Apo B）以及HDL胆固醇亚组分2（HDL(2)）和3（HDL(3)）。除LDL胆固醇外，所有血脂值均与自我报告的饮酒量呈正相关。排除饮酒者后，仅HDL胆固醇、HDL(3)和Apo A1的相关性显著。HDL胆固醇、HDL(3)和Apo A1的升高趋势首先在每日饮用>20 - 40克纯酒精的女性中明显可见。每日饮酒量>40克会使除LDL胆固醇外的所有血脂值升高。戒酒2周会导致HDL(3)胆固醇显著降低，LDL胆固醇和Apo B升高。结果表明，在中年女性中，Apo A1和通过其HDL(3)而非HDL(2)亚组分的HDL胆固醇可能在适度饮酒相关的有益冠状动脉后果中发挥作用。然而，有益趋势首先在每日饮酒量超过20克时出现。
