正常妊娠中内皮功能的无创评估。

Non-invasive assessment of endothelial function in normal pregnancy.

作者信息

Savvidou M D, Kametas N A, Donald A E, Nicolaides K H

机构信息

Harris Birthright Research Center for Fetal Medicine, King's College Hospital, London, UK.

出版信息

Ultrasound Obstet Gynecol. 2000 Jun;15(6):502-7. doi: 10.1046/j.1469-0705.2000.00131.x.

DOI:10.1046/j.1469-0705.2000.00131.x

PMID:11005118

Abstract

OBJECTIVE

To assess endothelial function in normal pregnancy by non-invasive methods.

METHODS

Flow-mediated dilatation of the brachial artery was measured by ultrasonography in 157 women with normal singleton pregnancies between 10 and 40 weeks' gestation and 19 non-pregnant controls.

RESULTS

Flow-mediated dilatation in the non-pregnant controls was 6.42 +/- 2.45%. In pregnant women, between 10 and 30 weeks, the mean flow-mediated dilatation (8.84 +/- 3.18%) was significantly higher than the non-pregnant controls (P = 0.002), but after 30 weeks of gestation there was a decrease to prepregnancy levels. Resting vessel diameter and blood flow were significantly increased in pregnancy, mainly after 30 weeks' gestation (P < 0.001, P < 0.001, respectively). Flow-mediated dilatation was significantly correlated to resting vessel diameter and reactive hyperemia.

CONCLUSION

Normal pregnancy is associated with enhanced endothelial function which is apparent from at least 10 weeks' gestation.

摘要

目的

采用非侵入性方法评估正常妊娠时的内皮功能。

方法

对157例妊娠10至40周的单胎正常孕妇及19例非孕对照者，通过超声测量肱动脉血流介导的血管舒张功能。

结果

非孕对照者血流介导的血管舒张功能为6.42±2.45%。在孕妇中，妊娠10至30周时，平均血流介导的血管舒张功能（8.84±3.18%）显著高于非孕对照者（P = 0.002），但妊娠30周后降至孕前水平。妊娠时静息血管直径和血流量显著增加，主要在妊娠30周后（分别为P < 0.001，P < 0.001）。血流介导的血管舒张功能与静息血管直径和反应性充血显著相关。