急性感染乙型肝炎病毒的黑猩猩血清和肝脏中的乙型肝炎抗原。
Hepatitis B antigens in serum and liver of chimpanzees acutely infected with hepatitis B virus.
作者信息
Berquist K R, Peterson J M, Murphy B L, Ebert J W, Maynard J E, Purcell R H
出版信息
Infect Immun. 1975 Sep;12(3):602-5. doi: 10.1128/iai.12.3.602-605.1975.
Abstract
We report the temporal patterns of various immunohistological and serological parameters of acute self-limited hepatitis B virus infection of two chimpanzees, and we provide evidence that the synthesis of hepatitis B core antigen precedes that of hepatitis B surface antigen. Our data suggest that existence of a biphasic hepatitis B virus infection involving a hematogenous reinfection of the liver and indicate that recruitment of liver cells to produce hepatitis B virus may occur in a pattern consistent with a replicative cycle of about 8 days.
摘要
我们报告了两只黑猩猩急性自限性乙型肝炎病毒感染的各种免疫组织学和血清学参数的时间模式，并提供证据表明乙型肝炎核心抗原的合成先于乙型肝炎表面抗原的合成。我们的数据表明存在一种双相乙型肝炎病毒感染，涉及肝脏的血源性再感染，并表明肝细胞产生乙型肝炎病毒的过程可能以大约8天的复制周期模式发生。
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