Pawelec G, Heinzel S, Kiessling R, Müller L, Ouyang Q, Zeuthen J
Section for Transplantation Immunology, University of Tübingen, Germany.
Crit Rev Oncog. 2000;11(2):97-133.
The current consensus of opinion has it that most or possibly all tumors, spontaneous as well as induced, are immunogenic, expressing antigens in a form recognizable by the host immune system. Accordingly, in order to progress, tumors have to evolve strategies for evading immune responses. The purpose of this review is to consider the current status of knowledge concerning these different tumor escape strategies. It represents an update of an article originally published in this journal in 1997 (Pawelec, Zeuthen, and Kiessling, 1997). Therefore, it focuses mostly on publications that have appeared since then, illustrating the impressive accumulation of new data since that time and the importance currently attributed to studies of tumor escape from the immune response.
目前的共识观点认为，大多数甚至可能所有肿瘤，无论是自发的还是诱发的，都具有免疫原性，以宿主免疫系统可识别的形式表达抗原。因此，为了进展，肿瘤必须进化出逃避免疫反应的策略。本综述的目的是考虑关于这些不同肿瘤逃逸策略的当前知识状态。它是对1997年发表在本杂志上的一篇文章（Pawelec、Zeuthen和Kiessling，1997年）的更新。因此，它主要关注自那时以来出现的出版物，说明了自那时以来新数据的惊人积累以及目前对肿瘤免疫逃逸研究的重视程度。
