Restifo Nicholas P, Antony Paul A, Finkelstein Steven E, Leitner Wolfgang W, Surman Deborah P, Theoret Marc R, Touloukian Christopher E
National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Semin Cancer Biol. 2002 Feb;12(1):81-6. doi: 10.1006/scbi.2001.0399.
The reasons why cancer cells are not destroyed by the immune system are likely to be similar, in most cases, to the reasons why normal cells are not destroyed by the immune system. Unfortunately for tumor immunologists, these reasons have not yet been fully elucidated. What is known, however, is that the lack of autoimmune destruction of normal tissue after immune activation is a finely regulated, highly orchestrated sequence of events. Viewed in this light, it is interesting to conceptualize the derangement of the tumor genome not merely as an engine that enables cancer cells to dodge immune recognition. The dysregulation characteristic of the transformed genome is also what makes tumor immunity, a specialized form of autoimmunity, possible.
在大多数情况下，癌细胞未被免疫系统摧毁的原因可能与正常细胞未被免疫系统摧毁的原因相似。对肿瘤免疫学家来说不幸的是，这些原因尚未完全阐明。然而，我们已知的是，免疫激活后正常组织未发生自身免疫性破坏是一系列精细调节、高度协调的事件。从这个角度来看，将肿瘤基因组的紊乱不仅仅概念化为使癌细胞逃避免疫识别的引擎是很有趣的。转化基因组的失调特征也是使肿瘤免疫（一种特殊形式的自身免疫）成为可能的原因。
