• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

线性无阈模型争议与“可控制剂量”概念

The LNT-controversy and the concept of "controllable dose".

作者信息

Kellerer A M, Nekolla E A

机构信息

Radiobiological Institute of the University of Munich, Germany.

出版信息

Health Phys. 2000 Oct;79(4):412-8. doi: 10.1097/00004032-200010000-00010.

DOI:10.1097/00004032-200010000-00010
PMID:11007464
Abstract

There is no firm scientific information on the potential health effects, such as increased cancer rates, due to low doses of ionizing radiation. In view of this uncertainty ICRP has adopted as a prudent default option the linear no-threshold (LNT) assumption and has used it to derive nominal risk coefficients. Subsequent steps, such as the comparison of putative fatality rates in radiation workers with observed accident rates in other professions, have given the risk estimates a false appearance of scientific fact. This has encouraged meaningless computations of radiation-induced fatalities in large populations and has caused a trend to measure dose limits for the public not against the magnitude of the natural radiation exposure and its geographic variations, but against the numerical risk estimates. In reaction to this development, opposing claims are being made of a threshold in dose for deleterious health effects in humans. In view of the growing polarization, ICRP is now exploring a new concept "controllable dose" that aims to abandon the quantity collective dose, emphasizing, instead, individual dose and, in particular, the control of the maximum individual dose from single sources. Essential features of the new proposal are here examined, and it is concluded that the control of individual dose will still have to be accompanied by the avoidance of unnecessary exposures of large populations, even if their magnitude lies below that acceptable to the individual. If a reasonable cut-off at trivial doses is made, the collective dose can remain useful. Misapplications of collective dose are not the deeper cause of the current controversy; the actual root is the misrepresentation of the LNT-assumption as a scientific fact and the amplification of this confusion by loose terminology. If over-interpretation and distortion are avoided, the current system of radiation protection is workable and essentially sound, and there is no need for a fruitless LNT-controversy. The new concept of controllable dose promises simplifications and improvements, but any major change of principles needs to be carefully considered in a broad discussion that ICRP is presently seeking.

摘要

关于低剂量电离辐射对健康的潜在影响,如癌症发病率增加等,目前尚无确凿的科学信息。鉴于这种不确定性,国际放射防护委员会(ICRP)采用了线性无阈(LNT)假设作为审慎的默认选项,并据此得出名义风险系数。后续步骤,如将辐射工作人员的推定死亡率与其他行业观察到的事故率进行比较,使风险估计呈现出科学事实的假象。这鼓励了对大量人群中辐射诱发死亡的无意义计算,并导致了一种趋势,即衡量公众剂量限值不是依据自然辐射暴露的大小及其地理差异,而是依据数值风险估计。针对这一发展态势,有人提出了人类有害健康效应存在剂量阈值的相反观点。鉴于分歧日益两极化,ICRP目前正在探索一个新的概念“可控剂量”,旨在摒弃集体剂量这一量值,转而强调个人剂量,尤其是对单一源产生的最大个人剂量的控制。本文对这一新提议的基本特征进行了审视,并得出结论:即使大量人群的辐射暴露量低于个人可接受水平,对个人剂量的控制仍须辅之以避免不必要的照射。如果对微不足道的剂量进行合理截断,集体剂量仍可发挥作用。集体剂量的不当应用并非当前争议的深层原因;真正的根源是将LNT假设错误地表述为科学事实,并因术语不严谨而加剧了这种混淆。如果避免过度解读和歪曲,现行辐射防护体系是可行的且基本合理,无需进行毫无结果的LNT争议。可控剂量这一新概念有望带来简化和改进,但原则上的任何重大改变都需要在ICRP目前正在寻求的广泛讨论中仔细权衡。

相似文献

1
The LNT-controversy and the concept of "controllable dose".线性无阈模型争议与“可控制剂量”概念
Health Phys. 2000 Oct;79(4):412-8. doi: 10.1097/00004032-200010000-00010.
2
LNT--an apparent rather than a real controversy?线性无阈模型——一场表面而非真实的争论?
J Radiol Prot. 2006 Sep;26(3):325-9. doi: 10.1088/0952-4746/26/3/N02. Epub 2006 Aug 22.
3
New ICRP recommendations.国际放射防护委员会新建议。
J Radiol Prot. 2008 Jun;28(2):161-8. doi: 10.1088/0952-4746/28/2/R02. Epub 2008 May 22.
4
The debate on the use of linear no threshold for assessing the effects of low doses.关于使用线性无阈模型评估低剂量效应的争论。
J Radiol Prot. 2006 Sep;26(3):317-24. doi: 10.1088/0952-4746/26/3/N01. Epub 2006 Aug 22.
5
Biological Effects From Low Doses and Dose Rates of Ionizing Radiation: Science in the Service of Protecting Humans, a Synopsis.低剂量和低剂量率电离辐射的生物学效应:服务于保护人类的科学,概要
Health Phys. 2018 Jun;114(6):623-626. doi: 10.1097/HP.0000000000000833.
6
Radiation doses and risks from internal emitters.体内辐射源的辐射剂量与风险。
J Radiol Prot. 2008 Jun;28(2):137-59. doi: 10.1088/0952-4746/28/2/R01. Epub 2008 May 22.
7
Linear-no-threshold is a radiation-protection standard rather than a mechanistic effect model.线性无阈是一种辐射防护标准,而非一种作用机制模型。
Radiat Environ Biophys. 2006 Mar;44(4):257-60. doi: 10.1007/s00411-006-0030-y. Epub 2006 Feb 9.
8
Logic and ethics in radiation protection.辐射防护中的逻辑与伦理
J Radiol Prot. 2001 Dec;21(4):377-80. doi: 10.1088/0952-4746/21/4/306.
9
The bell tolls for LNT.线性无阈值模型(LNT)敲响了丧钟。
Health Phys. 2004 Nov;87(5 Suppl):S47-50. doi: 10.1097/00004032-200411002-00004.
10
[Tremendous Human, Social, and Economic Losses Caused by Obstinate Application of the Failed Linear No-threshold Model].[顽固应用失败的线性无阈值模型造成的巨大人力、社会和经济损失]
Yakugaku Zasshi. 2015;135(11):1197-211. doi: 10.1248/yakushi.15-00188.

引用本文的文献

1
[Radiation hygiene in medical X-ray imaging. Part 3: radiation exposure of patients and risk assessment].
Radiologe. 2010 Nov;50(11):1039-52; quiz 1053-4. doi: 10.1007/s00117-010-2074-x.