Taussig M J, Munro A J, Campbell R, David C S, Staines N A
J Exp Med. 1975 Sep 1;142(3):694-700. doi: 10.1084/jem.142.3.694.
Further mapping of the mouse T-cell factor specific for poly(Try,Glu)-polyD-LAla--polyLys is reported. It is shown to be a product of the I-A subregion of the H-2 complex by the use of antisera either raised specifically against or made specific, by absorption, for different regions of the H-2 complex. The factor cooperates across allogeneic barriers, e.g., when factor produced by one strian is combined with bone marrow cells of other H-2 incompatible strains.
报道了对聚(色氨酸,谷氨酸)-聚D-丙氨酸-聚L-赖氨酸特异的小鼠T细胞因子的进一步定位。通过使用专门针对H-2复合体不同区域产生的抗血清或经吸收后对H-2复合体不同区域具有特异性的抗血清,表明它是H-2复合体I-A亚区的产物。该因子能跨越同种异体屏障发挥作用,例如,当一个品系产生的因子与其他H-2不相容品系的骨髓细胞结合时。