细胞协作中的抗原特异性T细胞因子。在H-2复合体I区内的定位及跨越同种异体屏障进行协作的能力。
Antigen-specific T-cell factor in cell cooperation. Mapping within the I region of the H-2 complex and ability to cooperate across allogeneic barriers.
作者信息
Taussig M J, Munro A J, Campbell R, David C S, Staines N A
出版信息
J Exp Med. 1975 Sep 1;142(3):694-700. doi: 10.1084/jem.142.3.694.
Abstract
Further mapping of the mouse T-cell factor specific for poly(Try,Glu)-polyD-LAla--polyLys is reported. It is shown to be a product of the I-A subregion of the H-2 complex by the use of antisera either raised specifically against or made specific, by absorption, for different regions of the H-2 complex. The factor cooperates across allogeneic barriers, e.g., when factor produced by one strian is combined with bone marrow cells of other H-2 incompatible strains.
摘要
报道了对聚（色氨酸，谷氨酸）-聚D-丙氨酸-聚L-赖氨酸特异的小鼠T细胞因子的进一步定位。通过使用专门针对H-2复合体不同区域产生的抗血清或经吸收后对H-2复合体不同区域具有特异性的抗血清，表明它是H-2复合体I-A亚区的产物。该因子能跨越同种异体屏障发挥作用，例如，当一个品系产生的因子与其他H-2不相容品系的骨髓细胞结合时。
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本文引用的文献
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Antigen-specific T-cell factor in cell cooperation: physical properties and mapping in the left-hand (K) half of H-2.细胞协作中的抗原特异性T细胞因子：物理性质及在H-2左手（K）半区的定位
J Exp Med. 1974 Dec 1;140(6):1579-87. doi: 10.1084/jem.140.6.1579.
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T cell factor which can replace T cells in vivo.可在体内替代T细胞的T细胞因子。
Nature. 1974 Mar 15;248(445):234-6. doi: 10.1038/248234a0.
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Antigen design and immune response.
Harvey Lect. 1973;67:213-46.
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Cell interactions between histoincompatible T and B lymphocytes. VII. Cooperative responses between lymphocytes are controlled by genes in the I region of the H-2 complex.组织相容性不相容的T淋巴细胞和B淋巴细胞之间的细胞相互作用。VII.淋巴细胞之间的协同反应受H-2复合体I区基因的控制。
J Exp Med. 1975 Jan 1;141(1):263-8. doi: 10.1084/jem.141.1.263.
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The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization.H-2主要组织相容性复合体与I免疫反应区：遗传变异、功能及组织结构
Adv Immunol. 1975;20:125-95. doi: 10.1016/s0065-2776(08)60208-4.
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Antigen-specific T-cell factors in the genetic control of the immune response to poly(Tyr,Glu)-polyDLAla--polyLys. Evidence for T- and B-cell defects in SJL mice.对聚（酪氨酸，谷氨酸）-聚-DL-丙氨酸-聚-L-赖氨酸免疫应答的遗传控制中的抗原特异性T细胞因子。SJL小鼠中T细胞和B细胞缺陷的证据。
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