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细胞协作中的抗原特异性T细胞因子。在H-2复合体I区内的定位及跨越同种异体屏障进行协作的能力。

Antigen-specific T-cell factor in cell cooperation. Mapping within the I region of the H-2 complex and ability to cooperate across allogeneic barriers.

作者信息

Taussig M J, Munro A J, Campbell R, David C S, Staines N A

出版信息

J Exp Med. 1975 Sep 1;142(3):694-700. doi: 10.1084/jem.142.3.694.

DOI:10.1084/jem.142.3.694
PMID:1100764
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2189912/
Abstract

Further mapping of the mouse T-cell factor specific for poly(Try,Glu)-polyD-LAla--polyLys is reported. It is shown to be a product of the I-A subregion of the H-2 complex by the use of antisera either raised specifically against or made specific, by absorption, for different regions of the H-2 complex. The factor cooperates across allogeneic barriers, e.g., when factor produced by one strian is combined with bone marrow cells of other H-2 incompatible strains.

摘要

报道了对聚（色氨酸，谷氨酸）-聚D-丙氨酸-聚L-赖氨酸特异的小鼠T细胞因子的进一步定位。通过使用专门针对H-2复合体不同区域产生的抗血清或经吸收后对H-2复合体不同区域具有特异性的抗血清，表明它是H-2复合体I-A亚区的产物。该因子能跨越同种异体屏障发挥作用，例如，当一个品系产生的因子与其他H-2不相容品系的骨髓细胞结合时。

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1
Antigen-specific T-cell factor in cell cooperation. Mapping within the I region of the H-2 complex and ability to cooperate across allogeneic barriers.细胞协作中的抗原特异性T细胞因子。在H-2复合体I区内的定位及跨越同种异体屏障进行协作的能力。
J Exp Med. 1975 Sep 1;142(3):694-700. doi: 10.1084/jem.142.3.694.
2
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[Role of the spleen in the differentiation of T-cells possessing an auxiliary function in the humoral immune reactions in the organism of lethally irradiated recipients of bone marrow transplants].
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The role of thymus cells in the immune response to poly(Tyr, Glu)-polyD L Ala--polyLys as a function of the genetic constitution of the mouse strain.作为小鼠品系遗传构成的一个函数，胸腺细胞在对聚（酪氨酸，谷氨酸）-聚D-L-丙氨酸-聚L-赖氨酸免疫反应中的作用。
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引用本文的文献

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Concanavalin A-inducible, interleukin-2-producing T cell hybridoma.伴刀豆球蛋白A诱导的、产生白细胞介素-2的T细胞杂交瘤
J Exp Med. 1980 Oct 1;152(4):893-904. doi: 10.1084/jem.152.4.893.
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Non-H-2 restriction of expression of passively transferred delayed sensitivity.被动转移迟发型超敏反应表达的非H-2限制
J Exp Med. 1982 May 1;155(5):1334-43. doi: 10.1084/jem.155.5.1334.
3
Helper and suppressor T cell factors.辅助性和抑制性T细胞因子。
Springer Semin Immunopathol. 1980 May;3(1):93-127. doi: 10.1007/BF00199927.
4
The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody.T细胞上主要组织相容性复合体限制的抗原受体。I. 用单克隆抗体进行分离。
J Exp Med. 1983 Apr 1;157(4):1149-69. doi: 10.1084/jem.157.4.1149.
5
Regulation of the human allogeneic proliferative response in vitro.人同种异体增殖反应的体外调节
Immunogenetics. 1981;14(1-2):107-16. doi: 10.1007/BF00344304.
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Role of self carriers in the immune response and tolerance. V. Reversal of trinitrophenyl-modified self suppression of the B-cell response by blocking of H-2 antigens.自身载体在免疫应答和耐受性中的作用。V. 通过阻断H-2抗原逆转三硝基苯基修饰的自身对B细胞应答的抑制作用。
J Exp Med. 1980 Jan 1;151(1):133-43. doi: 10.1084/jem.151.1.133.
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Triggering of affinity-enriched B cells. Analysis of B cell stimulation by antigen-specific helper factor or lipopolysaccharide. I. Dissection into proliferative and differentiative signals.亲和富集B细胞的触发。抗原特异性辅助因子或脂多糖对B细胞刺激的分析。I. 分解为增殖信号和分化信号。
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10
Immune response potential to poly(Tyr,Glu)-poly(DLAla)--poly(Lys) of human T cells of different donors.不同供体的人T细胞对聚（酪氨酸，谷氨酸）-聚（D-丙氨酸）-聚（赖氨酸）的免疫反应潜力。
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4505-9. doi: 10.1073/pnas.78.7.4505.

本文引用的文献

1
Antigen-specific T-cell factor in cell cooperation: physical properties and mapping in the left-hand (K) half of H-2.细胞协作中的抗原特异性T细胞因子：物理性质及在H-2左手（K）半区的定位
J Exp Med. 1974 Dec 1;140(6):1579-87. doi: 10.1084/jem.140.6.1579.
2
T cell factor which can replace T cells in vivo.可在体内替代T细胞的T细胞因子。
Nature. 1974 Mar 15;248(445):234-6. doi: 10.1038/248234a0.
3
Antigen design and immune response.
Harvey Lect. 1973;67:213-46.
4
Cell interactions between histoincompatible T and B lymphocytes. VII. Cooperative responses between lymphocytes are controlled by genes in the I region of the H-2 complex.组织相容性不相容的T淋巴细胞和B淋巴细胞之间的细胞相互作用。VII.淋巴细胞之间的协同反应受H-2复合体I区基因的控制。
J Exp Med. 1975 Jan 1;141(1):263-8. doi: 10.1084/jem.141.1.263.
5
The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization.H-2主要组织相容性复合体与I免疫反应区：遗传变异、功能及组织结构
Adv Immunol. 1975;20:125-95. doi: 10.1016/s0065-2776(08)60208-4.
6
Antigen-specific T-cell factors in the genetic control of the immune response to poly(Tyr,Glu)-polyDLAla--polyLys. Evidence for T- and B-cell defects in SJL mice.对聚（酪氨酸，谷氨酸）-聚-DL-丙氨酸-聚-L-赖氨酸免疫应答的遗传控制中的抗原特异性T细胞因子。SJL小鼠中T细胞和B细胞缺陷的证据。
J Exp Med. 1975 Mar 1;141(3):703-7. doi: 10.1084/jem.141.3.703.