对聚（酪氨酸，谷氨酸）-聚-DL-丙氨酸-聚-L-赖氨酸免疫应答的遗传控制中的抗原特异性T细胞因子。SJL小鼠中T细胞和B细胞缺陷的证据。
Antigen-specific T-cell factors in the genetic control of the immune response to poly(Tyr,Glu)-polyDLAla--polyLys. Evidence for T- and B-cell defects in SJL mice.
作者信息
Mozes E, Isac R, Taussig M J
出版信息
J Exp Med. 1975 Mar 1;141(3):703-7. doi: 10.1084/jem.141.3.703.
Abstract
The cellular basis of the genetic control of the immune response to poly(LTyr, LGlu)-polyDLAla--polyLLys [(T,G)-A--L] in SJL (H-2s, low responder) mice has been investigated using T-cell factors. Thymocytes of SJL origin were educated to (T,G)-A--L and tested for their ability to produce an antigen-specific factor capable of cooperating in vivo with bone marrow cells of either SJL or C3H.SW (high responder) origin. SJL T cells were found to be incapable of producing such a cooperative factor, in contrast with results previously obtained with C3H/HeJ (low responders) and C3H.SW strains. Moreover, SJL bone marrow cells did not produce an antibody response to (T,G)-A--L, even when combined with factor produced by high responder (C3H.SW) mice. Thus, both T and B cells appear to be defective in the SJL strain in the response to (T,G)-A--L.
摘要
利用T细胞因子，对SJL（H-2s，低反应者）小鼠针对聚（L-酪氨酸，L-谷氨酸）-聚-D-丙氨酸-聚-L-赖氨酸[（T，G）-A-L]的免疫应答的遗传控制的细胞基础进行了研究。将源自SJL的胸腺细胞用（T，G）-A-L进行诱导，并检测它们产生能够在体内与源自SJL或C3H.SW（高反应者）的骨髓细胞协同作用的抗原特异性因子的能力。与先前用C3H/HeJ（低反应者）和C3H.SW品系获得的结果相反，发现SJL T细胞无法产生这种协同因子。此外，即使与高反应者（C3H.SW）小鼠产生的因子结合，SJL骨髓细胞也不会对（T，G）-A-L产生抗体应答。因此，在对（T，G）-A-L的应答中，SJL品系的T细胞和B细胞似乎均存在缺陷。
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