Carosella E, Bensussan A, Lepage V, Sasportes M
Immunogenetics. 1981;14(1-2):107-16. doi: 10.1007/BF00344304.
We have investigated the glass-wool-adherent characteristics of human lymphocytes able to suppress allogeneic proliferation in vitro. We observed that: (1) Suppressor cells obtained after in vitro priming and their precursors are adherent to glass wool, whereas cytotoxic cells and their precursors are not; (2) primed cells adherent to glass wool are mainly HLA-DR positive, while nonadherent cells are HLA-DR negative or weakly positive; (3) the nonadherent, unprimed T cells used as responder cells in a primary MLR are more readily suppressed by suppressor cells than the same cells unfiltered. This may suggest an enrichment of 'acceptor' cells for suppression.
我们研究了能够在体外抑制同种异体增殖的人淋巴细胞的玻璃棉黏附特性。我们观察到：（1）体外致敏后获得的抑制细胞及其前体可黏附于玻璃棉，而细胞毒性细胞及其前体则不能；（2）黏附于玻璃棉的致敏细胞主要为HLA-DR阳性，而未黏附细胞为HLA-DR阴性或弱阳性；（3）在初次混合淋巴细胞反应中用作反应细胞的未黏附、未致敏T细胞比未过滤的相同细胞更容易被抑制细胞抑制。这可能提示存在用于抑制的“受体”细胞富集现象。
